DNA sequencing

Describe the limitations of traditional methods of Identifying bacteria. Traditional methods include judging by phenotypes characteristics. This could be a problem if two bacteria looked similar because they could easily be confused. Summarize the goal of each of the six parts of the lab. Sample Prep First we need to extract the DNA from the bacterial wall PC Amplification Create millions of copies of the initial DNA PC purification Filter out DNA from primers and enzymes Sequencing Prep Run more PC to make copies of DNA at various lengths DNA SequencingSequence machine runs gel electrophoresis to Identify nucleotides and determine sequence. Sequence Analysis Computer determines full DNA sequence which can be run and compared. Explain how fluorescent markers help determine a nucleotide sequence. Each nucleotide is assigned a certain color. Conclusion 1 How can scientists identify specific bacteria when they are amplifying and studying the same region of DNA In each species? They can identify it because there are unique sequences for each species. If you take a sample and find the DNA of it you can then compare it to the Dona's of known bacteria to discover what bacteria the sample is from

Educational Preparation Essay

There are many differences in the competencies of Associate Degree in Nursing (ADN) and Bachelor’s of Science in Nursing (BSN) graduates. To start, I think it is best to look at the through the perspective student’s eyes when they are deciding which type of program to attend. The first question one may ask is â€Å"How long is this going to take?† On average, an ADN program takes 3 years to complete, the BSN requires a minimum of 4 yeas. The difference in the length of programs is first based on the amount of prerequisites required. â€Å"While Associate Degree in Nursing students do need to take science prerequisites and some liberal arts classes, they don’t have to earn nearly as many credits in this area as BSN students do.† (ADN vs BSN Debate I Difference in Competencies, Salary & Education.2013) â€Å"Instead of the sixty-six nursing credits that a BSN student must complete, the student in the associate degree program needs forty-nine nursing credits† (ADN vs BSN Debate I Difference in Competencies, Salary & Education.2013) Therefore, the ADN program takes less time to complete, is more condensed, and is more focuses on clinical skills. BSN programs have a direct goal of not only graduating clinically competent nurses, but nurses that understand that this profession is deeply rooted in science and theory. The differences in competencies between the ADN and BSN nurse is based on this understanding of science. If you had to explain what science is in one word that word would be â€Å"why†. BSN programs are typically centered around critical thinking and evidence based practice – they â€Å"why† of nursing. â€Å"Numerous research studies have demonstrated that the ADN and BSN nurses are not different in skill competency when they graduate, but within a year, the BSN nurses show greater critical thinking skills, better problem solving, and the development of clinical judgment; three skills of increasing importance for the increase in acuity of patients in hospitals and other health care settings.† (West Coast University: Dean’s Corner – The Differences Between Associate Degree Nurses and the Baccalaureate Degree Nurses.2009) The ability to use critical thinking when caring for a patient is what defines all other competencies. Competencies aren’t based on just the task the nurse is about to complete, but knowing why she is working towards completing this task. Without that training in understanding the â€Å"why†, her competencies are limited to just tasks. A fast growing trend in nursing today is complex technology used in patient care. Often times the nurse finds herself faced with not only caring for the patient, but managing high-tech equipment involved in that patient care. Being a resourceful nurse is not just beneficial, but crucial to patient care. BSN prepared graduates are experts in research due to the expectations in the BSN curriculum. â€Å"A major concern in an era of evidence-based practice is that the majority of practicing nurses have not experienced a formal research course. These classes are generally lacking outside of the baccalaureate curriculum. It would seem that an understanding of the research process would be necessary to deliver optimal patient care† (Ayers & Coeling, 2006; Thorpe & Smutko, 1998). The ability to conduct research appropriately is a skill that is taught. We live in an age where information is just a click away. If a nurse isn’t using the correct resources, the patient is the one that suffers. The push for continuing education in nursing is one of the many forces that shaped what nursing is today. The BSN prepared nurse encompasses the ability to be resourceful, a bold and capable critical thinker, and one that will lead the profession into a strong future. As a nurse, we should never settle for just the standards put in front of us. We should always be looking for a way to improve patient care for the individual patient, as well as the practice of nursing as a whole. To settle for just the minimal requirements and standards of nursing is to just complete the tasks assigned to us. Developing critical thinking is what brings us to better patient outcomes. Learning to think ahead – planning for the worst, expecting the best is what restores patient health. The human body is a dynamic, complex integration of systems working in unison to maintain life. If one of those systems is not working correctly the nurse is cued in because of our critical thinking skills. It is what keeps the nurse’s brain â€Å"on†, assessing at a constant. It’s not always the system we’re â€Å"caring for† that tells us what is wrong. This is where the critical thinking comes in. We should always be asking â€Å"why† as a nurse. References ADN vs BSN Debate I Difference in Competencies, Salary & Education. (2013). Best Nursing Schools, Degrees & Online Nursing Programs. Retrieved January 13, 2013, from http://www.bestonlinenursingprograms.com/3356/adn-vs-bsn-debate Ayers, D., & Coeling, H. (2006). Incorporating research into associate degree nursing curricula. Journal of Nursing Education, 44(11), 515-518. West Coast University: Dean’s Corner – The Differences Between Associate Degree Nurses and the Baccalaureate Degree Nurses. (2009, February). West Coast University – Nursing Programs – Los Angeles, Orange County, Inland Empire. Retrieved January 13, 2013, from http://www.westcoastuniversity.net/deanscorner/print.php?article=22

Financial Ratios and Stock Return Predictability

The results indicate that DY and EY ratios has direct positive association with stock return where as B/M ratio has significant negative relationship with stock return. Therefore we can say that the above mentioned ratios are able to predict stock returns, furthermore it can be seen that as compare to dividend yield and earning yield the ratio of book to market has the highest predictive power. Moreover when we combine these financial ratios the predictability of stock returns will enhance. Keywords: Financial ratios, Stock return, Karachi Stock Exchange, Dividend Yield, Earning Yield. 1.Introduction Stock Market plays a very significant role in the economic growth of a country. According to A. Schrimpf (2010) there is significant economic aftermath of the existence of stock return predictability. S. Kheradyar et al, (2011), â€Å"The Analytics of Economic Time Series†, states that in stocks market share prices move randomly i. e. on certain day share prices are like to go dow n as they were like to up. Such random behavior worried some of the financial economists and followed by further research. Hence such random movement of share prices lead to a hypothesis called Random Walk Hypothesis.Random walk hypothesis suggest that it is difficult to predict share prices because stock prices evolved, now it will be showing upward trend but after some time such might be showing downward trend. Hence predicting 100% accuracy of stock return is almost impossible. In contrast to Random Walk Behavior is efficient market hypothesis. According to efficient market hypothesis share prices are fairly priced in the stock market or prices of stock demonstrates information in the market is widely and equally available to all and no one in the market can outperform or can beat the market.With the passage of time researchers tries to find out most accurate variables for predicting stock prices, some were tend towards financial and some were towards profitability ratios i. e. b ook to market ratio, price to earnings ratio, 1 Research Journal of Finance and Accounting ISSN 2222-1697 (Paper) ISSN 2222-2847 (Online) Vol 3, No 10, 2012 www. iiste. org dividend yield, etc some were tend towards cash flow ratios like price to cash flow ratio, cash burn ratio, etc and some focused on macroeconomic variable like interest rate, law and order situation and inflation rate etc.In this research article we have investigated 3 above mentioned ratios to determine whether they predict stock returns. This research study has used the stock return and the above mentioned financial ratios association at two samples as the foundation for the formulation of Eight hypotheses. On the grounds of their appropriate regression models the eight hypotheses are divided into two sets. In this study we have used the two models of simple and multiple regressions to apply Predictive regression; it is an important tool for predicting stock returns. A set of panal data is used for the formulat ion of these two models.For tackling the problem of heteroskedasticity and non-normality distributed residuals, we applied generalized least squares method. 2. Literature Review Campbell and Shiller (1988) stated in their study that as dividend yield has the ability to confine expected return and expectation about growth in dividend yield so dividend yield is good predictor of stock return. Chan, L. Hamao, Y. Yakonishok, J. (1991), found that in Japanese market fundamental variables like dividend yield, price to earnings ratio, book to market ratio and firm’s size have significant impact on expected earning/returns of stocks.They notify that there is indirect relationship between earning yield and stocks returns in Japan. In comparison of the size of the firm and earning yield, B/M and dividend yield (cash flow yield) are significantly related with returns of stocks. They further added that an important variable both economically and statistically is book to market ratio and this need to be observe because either the afterward half of the sample is judged or for the first time test is applied the book to market ratio shows it continuation. Mukerji, S. Dhatt, M. Kim, Y. 1997), on Korean Stock market for a period of 1982-1992 establish a direct relationship between return of stocks and D/E, S/P and B/M, moreover an indirect relationship between size of firm and return of stocks. They demonstrated that P/E ratio is less trustworthy indicator than B/M and S/P. Beta is a week proxy for assessment of risk when compare with debt to equity ratio. B/M and S/P are responsible for the direct relationship between return of stocks and debt to equity. However a P/E and B/M ratio becomes the base for indirect relationship between return of stocks and size of the firm.Kothari and Shanken (1997) found for US market that dividend yield and book to market ratios have dependable proof for expected real return over a period 1926-1991, and there lies a track of time series v ariations. Pontiff and Schall (1998) stated that as for predicting power is concerned book to market ratio has some predictability power for predicting stock returns. Lewellen (2002) conducted his study in US he found that predictability power of dividend yield for predicting stock returns is more than P/E and B/M ratios.Ang, A. , and Bekaert, G. , (2006), in their studies tried to forecast interest rate and stock returns with the help of predictive power of dividend yield. They found for short term forecasting, dividend yield predictive power is more than the long term forecasting. But as for the expected growth of cash flow prediction is concerned than dividend yield is a good predictive variable. Akyol, A. (2006), â€Å"analyzed the effect of firm’s size, beta, and book-to-market value on the stock returns in Istanbul stock exchange.He used data from July 1993 to December 2005 for Istanbul Stock Exchange and used Fama and French (1992) methodology to construct portfolios represented accurately by size-beta and then size-book-to-market, he found that book to market and Beta of a firms have no effect on the stock return’s in Istanbul stock exchange. Size of the firm was the only variable which was negatively related to the stock returns in Istanbul stock exchange. He also found that book to market, size and beta is not related with January effects. Hjalmarsson, E. (2004), in his study tried to find out Global stock returns predictability.He took twenty thousand monthly observation form forty international stock markets. In which 24 were of developed economy and 16 were of developing economy. However his study showed that dividend yield and price to earnings ratio has little power of predictability and defends his conclusion by adding that international result is showing deviation from traditional view because the method use internationally may not count for determination of variables. 2. 1 Hypotheses H1: return of stock and DY has no associatio n in time (t) and (t-1) respectively in sample one.H2 return of stock and EY has no association in time (t) and (t-1) respectively in sample one. H3: return of stock and B/M has no association in time (t) and (t-1) respectively in sample one. H4: return of stock and DY has no association in time (t) and (t-1) respectively in sample two. H5: return of stock and EY has no association in time (t) and (t-1) respectively in sample two. H6: return of stock and B/M has no association in time (t) and (t-1) respectively in sample two. 2 Research Journal of Finance and Accounting ISSN 2222-1697 (Paper) ISSN 2222-2847 (Online)Vol 3, No 10, 2012 ww. iiste. org H7: return of stock and DY, EY, B/M combination has no association in time (t) and (t-1) respectively in sample one. H8: return of stock and DY, EY, B/M combination has no association in time (t) and (t-1) respectively in sample two. 3. Research Methodology In order to check predictability power of earning yield, dividend yield and book t o market ratios for predicting stock returns the study has taken a sample of 100 firms for a period of 2005-2011. We have applied certain screening criteria’s for companies to be included in the sample.First, the firm must be listed on the KSE before Jan 1st 2005. 2nd, for more than twelve months a stock must not be deferred. 3rd, for the study period of seven years a company stock must not be delisted. 4th, data must be available for all sample firms and variables. Finally, for a period of more than twelve months the dividend yield of firms must not be zero. The study has divided the selected firms into two equal samples, which will reduce the effects of random sampling errors and for the predictive regression two samples produce different estimation.The study is based on secondary data, which is collected from, â€Å"State Bank of Pakistan†, company’s annual reports, business recorder and from â€Å"Karachi stock exchange†. Following S. Kheradyar et al, (2011) this study includes stock returns as dependent variable while dividend yield, earning yield and B/M ratios has been taken as independent variables. 4. Measurement of Variables 4. 1 Stock Return Following Lewellen (2001) and S. Kheradyar et al, (2011) we have used stock return as dependent variable.Stock return is measured by dividing capital gain along with dividend per share on market price per share. Following is the formula for stock returns. SRi = DPs + capital gain/market price 4. 2 Book to Market Ratio For finding value of company by comparison of market value of a share to its book value, study tends towards book to market ratio. For finding book value of a firm the study divide equity of a firm by its total number of outstanding shares. As for market price is concerned study tend towards the ongoing price of share in stock market.If a firm offer high return and having high book value than its market value, the firm is riskier and in future returns of stock will be lo wered than today. The following formula is used for calculating book to market value: B/M = Book Value per share Market value per share Lewellen (2001) states that as compare to P/E ratio B/M has higher predictive power for predicting stock return. But when study compare B/M ratio with dividend yield than dividend yield is good forecaster than B/M ratio. 4. 3 Dividend yield Following S.Kheradyar et al, (2011) second independent variable in this study is Dividend yield which is calculated as dividing dividend per share on market price per share. If market price is lower than dividend yield will be higher and give a riskier signal for investment. Contrast to higher dividend yield is low dividend yield; such happen when market price per share is higher than dividend yield and gives an optimistic view for investment.The following formula demonstrates how to calculate dividend yield: Dividend Yield (%) = (Dividend per Share / Market rate per share) x 100 4. Earning Yield The empirical li teratures lay foundations of the predictive power of earning yield on stock return, and find out the association between earning yield and stock return is considerable, because earning yield plays as a risk factor in relation with stock return. Moreover, the earning yield can demonstrate the efficiency of market that has an important role in emerging markets, thus this study uses earning yield as the empirical predictor of stock return. Following S. Kheradyar et al, (2011) we have measured earning yield as earning per share divided by price of share. 5.Regression Model In this research article we have investigated three financial ratios EY, DY and B/M to determine whether they predict stock returns. This research study has used the stock return and the above mentioned financial ratios association at 3 Research Journal of Finance and Accounting ISSN 2222-1697 (Paper) ISSN 2222-2847 (Online) Vol 3, No 10, 2012 www. iiste. org two samples as the foundation for the formulation of Eight hypotheses. On the grounds of their appropriate regression models the eight hypotheses are divided into two sets.In this study we have used the two models of simple nd multiple regressions to apply Predictive regression; it is an important tool for predicting stock returns. A set of panal data is used for the formulation of these two models. For tackling the problem of heteroskedasticity and non-normality distributed residuals, we applied generalized least squares method. Following S. Kheradyar et al, (2011) we have used panal models to formulate predictive regressions. Hence we have used simple regression model to test the first 6 hypothesis which are formulated on the basis of association between each financial ratio and future stock returns.The simple regression model has the following form: SR it = ß0 + ßi Xi (t-1) + eit Where, SR it= in time period t, the return of ith stock, ß0= the estimated constant, ßi= ith stock predictable coefficient, Xi (t-1) = in period t-1 financial ratios of the ith stock, eit = error term. Similarly following S. Kheradyar et al, (2011) we have used multiple regression model to test the other two hypotheses H7 and H8, these two hypotheses are formulated on the basis of relationship between combined financial ratios and future stock returns.The model has the following form: SR it = ß0 + ßi1 DYi (t-1) + ßi2 EYi (t-1) + ßi3 B/Mi (t-1) + eit Where, SR it= in time period t, the return of ith stock, ß0= the estimated constant, ßi1= for DY the Ith stock predictable coefficient, ßi2= for EY the Ith stock predictable coefficient, ßi3= for B/M the Ith stock predictable coefficient, DYi (t-1) = is ith stock DY factor in period of time t-1, EYi (t-1) = EY factor of ith stock in period of time t-1, B/Mi (t-1) = B/M factor of ith stock in t-1 time period, eit = error terms. 6.Results and Discussion For the first 6 hypothesis the predictive regression results are summarized in Table 1. The coefficient of di vidend yield in Table 1 demonstrates a positive relationship of dividend yield in period (t-1) and stock returns in period (t) in both samples that is when dividend yield increases by one unit it will cause an increase of 0. 021 and 0. 010 units in stock returns of two samples respectively. As for the p-value of coefficient of Dividend yield is concerned it is 0. 016 in sample one which is less than 0. 5, so the relationship is statistically significant and the null hypothesis H1 is rejected, however in sample two the association is insignificant so hypothesis H4 cannot be rejected.The coefficient of earning yield in Table 1 demonstrates a positive relationship of earning yield in period (t-1) and stock returns at period (t) that is when earning yield increases by one unit it will cause an increase of 0. 013 and 0. 008 units in stock returns in the two samples respectively. As for the p-value of coefficient of earning yield is concerned it is 0. 19 and 0. 010 in the two samples resp ectively which is less than 0. 05, so the relationship is statistically significant, therefore we will reject hypothesis H2 and H5. The negative coefficient of Book to market value in table 1 notifies an inverse relationship of B/M and stock returns in both samples that is if B/M ratio increasing the stock return will be decreasing and vice versa. The p-value of coefficient of B/M value 0. 000 indicates that the relationship is statistically significant in both samples, so hypothesis H3 and H6 have been rejected.S. Kheradyar et al, (2011) found that DY has negative influence on stock return, and a positive association between EY and stock return. He also found a positive impact of B/M on stock return in (2) (1) 4 Research Journal of Finance and Accounting ISSN 2222-1697 (Paper) ISSN 2222-2847 (Online) Vol 3, No 10, 2012 www. iiste. org sample 2 but a negative one in sample 1. It can also be noticed by looking at the adjusted R-square that B/M has the highest predictive power, and th is result is also supported by S. Kheradyar et al, (2011). Insert Table 1 Here) Now we will test to see whether stock return predictive power increases with the combination of EY, BM and DY. We will reject H7 and H8 because it can be seen in Table 2 that the predictive regressions are statistically significant. Thus we can say that stock return can be predicted by the combination of EY, BM and DY. Also we can say that as compare to the other two ratios, the variations of the ratio of book to market has greater impact on stock return, because in both samples it has the highest coefficient.Similarly by looking at the adjusted R-square we can say that in the two samples stock return predictive power increases when the combination of EY, BM and DY increases. (Insert Table 2 Here) 6. Conclusion Literature regarding predictability of stock returns has changed over the last 20 years. With evolution researchers and economists separated price to earnings ratio, dividend yield, inflation, and book to market ratio, beta, industry returns, interest rate, and size of firms from amongst other variables which were considered important for predicting return of stocks.Presently strong evidences are present regarding variables for predicting stock returns. Analysis showed that financial ratios have significant power of predictability for forecasting returns of stock and they predict future stock return of Pakistani market, and B/M has higher predictive power as compare to other ratios. Similarly the predictability of stock return is enhanced by the combination of financial ratios. References A. Schrimpf, (2010). International Stock Return Predictability under Model Uncertainty. Journal of International Money and Finance, 29: 1256-1282. S. Kheradyar, I. Ibrahim, and F.Mat Nor, (2011). Stock Return Predictability with Financial Ratios. International Journal of Trade, Economics and Fiance, 2(5): 391-396. J. Y. Campbell, and R. J. Shiller, (1988). Stock Prices, Earnings and Expecte d Dividends. Journal of Finance, 43(3): 661-676. Chan, L. Hamao, Y. Lakonishok, J. (1991). Fundamental and Stock Returns in Japan. The Journal of Finance, 17391764. Mukerji, S. Dhatt, M. Kim, Y. , (1997). A Fundamental Analysis of Korean Stock. Financial Analyst Journal, 53: 7580 Kothari, S. P. , Jay A. Shanken, (1997). Book-to-Market, Dividend Yield and Expected Market Returns: A TimeSeries Analysis.Journal of Financial Economics 44: 169-203. J. Pontiff, and L. Schall, (1998). Book-to-Market Ratios as Predictors of Market Returns. Journal of Financial Economics, 49: 141–160. Lewellen, J. , (2002). Predicting Returns with Financial Ratio. National Bureau of Economics Research, MIT working paper no. 4374-02 Ang, A. and Bekeart, G. , (2006). Stock Returns Predictability. The Review of Financial Study, 651-707. E. F. Fama and K. French, (1992). The Cross-Section of Expected Stock Returns. Journal of Finance, 47: 427-465 Lewellen, J. , (2001). Predicting Returns with Financial Ra tios. Journal of Financial Economic, 209-235.

Critical Reflection Report Essay Example | Topics and Well Written Essays - 1000 words

Critical Reflection Report - Essay Example I do not see worth in talking, discussing government decisions and weighing the pros and cons, offering alternatives etc. I consider it a waste of time, because government is not the business of citizens. Australians do not think that way. They are nosy, argumentative, and fly off the handle easily. Sometimes I feel they get excited for nothing. We are happy because Chinese work hard, building a strong, healthy, economically viable, ideologically Communist future China, which can challenge any country. We have achieved a lot, economy is stable and growing, reduced the population, and remained totally disciplined and committed. When I came to Australia, this belief underwent sea change. First there was a cultural shock of politics and way of life. I was unprepared to the absolute difference in Australian society, government and values posed in front of me. Initially I lived within the Chinese group. This clannish grouping provides security and avoids confusion. Slowly I expanded by friends' circle into Australian students, who are absolutely nonchalant about international students and I ventured into a totally different world. Australians are proud of their heritage, continent/country, and feel that it is a matter of achievement that a country of convicts could build a modern egalitarian society, in a rough, unexplored land. Their love for music, entertainment is louder than their white counterparts in Western countries and they have a good sense of humor. They gamble, drink, rejoice and while older people go to pubs more, people of my generation prefer discos and that was an enchanting world for me where I could meet many friendly girls and boys. Australian food has many Anglo-Celtic and European dimensions I was told, and the traditional aboriginal food like dishes made out of kangaroo meat, emu, snake, eel etc. are not uncommon and Australians are tremendous eaters and that has never stopped amazing me although I like their food. Comparatively Chinese live frugally. Holidays, travelling, festivals, actually any reason to rejoice never go waste in australia. Again in China we are rigid, regimentalised about holidays and missing work. Here the social life is friendly, laid back, easy going, loud and gay. There cannot be a greater contrast than in the political system of the two countries. In a way, looking at their isolation, it is surprising that they are not terribly territorial. There is stark contrast in every field. Drawing a comparison is almost impossible, while contrasts are aplenty. I think Australians have a confused and a bit low opinion about China's politics. To me it looks calm and organized, compared to the noisy street politics of Australia. Quantifying any experience is not easy; still I should admit that I liked this new experience. I know we make an economic impact, and have social value; students here are keen to know about us, just as we are about them. We know more about democratic way of life and its institutions. Though there is no longing for them, it is necessary to know the contrasts. Crossing national borders could be foundation for future ventures keeping up with the globalization and Australians understand our situation. "They usually encounter an unfamiliar culture with a different set of behavioural standards, new institutions and sets of rules associated with them, a foreign language, and an

Analysis of the Death Penalty and Presidential, Parliamentary Systems Essay

Analysis of the Death Penalty and Presidential, Parliamentary Systems - Essay Example Justices can often state in their decisions what they believe is right or wrong, but this can sometimes be in contradiction to their overall decision. Thus, overall, a Supreme Court decision would offer a verdict and explain that it is valid because it complies with the Constitution and other laws. An editorial would be more rhetorical in nature, as it would not cite the legality of the death penalty as well as its preceding use as evidence supporting its current use, as this would be arguing why the death penalty is Constitutional or not. Instead, the editorial would persuade the reader why the death penalty is or is not necessary, efficient, or of use, regardless of its legal status, and thus the writer would have a goal of being subjective and persuasive rather than objective and decisive. 2. Official agreements between countries tend to closely resemble the structure of a contract. They provide for the conditions of the contract, the duration of the contract, and who is involved. They would also list exceptions and contingencies for violation of the contracts. It would, of course, be written and express, rather than being verbal or implied, so that the relationship and agreement between countries are clearly defined and stated.

Protein purification using anion exchange membranes Term Paper

Protein purification using anion exchange membranes - Term Paper Example This change results in the protein being less capable of forming a strong ionic interaction with negatively charged cation exchanger. A similar chain of events occurs with anion exchange media. At a lower pH of the mobile phase the target molecule becomes more protonated and hence positively charged. The result is that the target molecule no longer has the capability to form a strong ionic interaction with the positively charged anion exchanger which causes the molecule to elute from stationary phase. Ion exchange is the most commonly practiced chromatographic method of protein purification due to its ease. This technique exploits the amphoteric character of a protein ( net positive in low pH buffer and negative in a high pH buffer). The technique exploits the fact that the distribution and net charge on the protein’s surface determines the interaction of the protein with the charged groups on the surface of the immobile phase, an anion exchange membrane in this case. The char ges on the protein and the membrane must be opposite for the exchange interaction to occur. The support membrane, which has covalently attached positive functional groups, is referred to as an anion exchanger if mobile negatively charged anions will be the exchanged species. ... In membrane chromatographic processes, the transport of solutes to their binding sites take place predominantly by convection and the pore diffusion is very small comparing with the beads column, thereby the mass transfer resistance is tremendously reduced. Membrane chromatography is a promising process for the isolation, purification, and recovery of proteins, enzymes, and nuclear acids. Comparing with traditional beads column chromatography, membrane chromatography can be faster, easier and cheaper to mass-produce. And also, it is easy to set up and scale up. Most important is saving time in membrane chromatography, this is important because many proteins lose their activities with time. Membranes are also more convenient because they do not require column hardware or packing, they reduce buffer usage and floor space requirements and they generally improve manufacturing flexibility. There are mainly three shapes of membrane available, including flat sheet, hollow fiber and radial f low used for protein purification (2). (From http://www.natrixseparations.com/media/application_note7.pdf) Figure 1 Principles of an anion exchange chromatography: Lowering pH on the protein elution from positively charged anion-exchange membrane. Molecules with higher charge density bind much stronger to the membrane and consequently require greater change in pH to be released from the membrane surface. Theory: Proteins are bound to anion exchange membranes by reversible, electrostatic interactions. A separation is obtained because the diverse array of molecular species have different affinities for the exchanger. The adsorbed proteins are eluted in order of least to most strongly bound molecules,

Women, Work and Family Essay Example | Topics and Well Written Essays - 2500 words

Women, Work and Family - Essay Example Violating equal employment opportunity laws in favor of males is as good as adopting unfair practices by employers. However, all these interpretations are subjective and different people have different interpretations. In the US, unfair practices in regard to women at the workplace can be determined by ascertaining whether the following laws are being complied with. Wage discrimination is prohibited by employers on the basis of sex under provisions of the Equal Pay Act of 1963, which is a part of the Fair Labor Standards Act. Section VII of the Civil Rights Act of 1964 disallows workplace discrimination in regard to reducing workforce, firing, hiring and sexual harassment Discrimination of pregnant women is prohibited under the Pregnancy Discrimination Act. If assumptions are made on the basis of previously established practices about the working roles of women and men, women can be said to be discriminated against if they are being denied opportunities on the basis of such assumptio ns. This becomes an unfair practice because then, women are treated unfairly on the basis of gender. An employer cannot make assumptions about the kind of work that a woman is able to do and then reject her application. This too is an unfair practice because opportunity is denied at the work place. However, given that discrimination has become quite ingenious many women continue to suffer from unfair discrimination in employment. Fairness at the workplace requires a consistent commitment in eliminating illegal discrimination and unless this objective is achieved, the American values of equal opportunity and fairness will not be met (Wilson, 2003). It is ironical that as per data provided by the Census Bureau... This paper stresses that global corporations need to adopt and implement strong initiatives to achieve gender equality through adoption of measures such as the implementation of employment practices and policies that entirely remove gender inequality in issues such as promotion, pay and recruitment. Major elements in this regard will include the payment of the legal wages to women and ensuring fair and comparable working conditions such as retirement benefits, working hours and wages. In keeping with global practices, new initiatives should include confirmable actions whereby women are given equal opportunities in terms of representation. The maximum attention needs to be given to introducing measures for prohibiting discrimination on the basis of marriage status and parental status while taking decisions about promotions and employment. This also includes actions focusing on ensuring job security, which permit interruption in the job because of maternity leave, parenting leave and f amily related responsibility. This esssay makes a conclusion that global organizations can improve the system relative to equality of women in the workplace by taking initiatives of implementing impartial policies towards women engaged in contractual work and temporary work. Layoffs need to be managed in ways that women are not impacted disproportionately. It is thus true that global employment needs global justice whereby employers cannot treat female employees in ways they would not treat male employees.

Decline in Global Income Inequality Research Paper

Decline in Global Income Inequality - Research Paper Example   Globalization has resulted in multicultural societies that have encouraged cross-cultural understanding and mutual respect. The societies across the globe have become more tolerant. At the same time, the governments across the globe have introduced radical reforms in their socio-economic and political system to make people from different culture, race and nationality adjust within the new social order with more ease. The businesses have also realized the need to incorporate changes that would need the changing requirements of the fast transforming dynamics of the societies. The compulsions of the contemporary times have therefore promoted the need for the common goal and collective responsibility for peaceful co-existence.   According to Stiglitz (2007), globalization has brought in more influx of multinational companies in the developing countries which have all negotiated with the intent purpose of benefiting the parent companies. The monopoly of American influence in all the leading international financial institutes like World Bank and IMF have followed the American policy of one-way transparency whereby the developed and under-developed countries, must open their market and relax their laws to suit the interests of the multinational companies. While it may be true to a certain extent, it also cannot be denied that business from developed countries has significantly improved the economy of underdeveloped countries and facilitated the socio-economic growth of the developing nations. Firebaugh (2004) has also affirmed that globalization had actually operated to boost industrialization in the developing countries.   

Mexico, The Mexican Drug Cartel Research Paper Example | Topics and Well Written Essays - 1250 words

Mexico, The Mexican Drug Cartel - Research Paper Example The official language of the country is Spanish and it is marked as the â€Å"most populous Spanish-speaking country in the world.† Christianity is the religion that is practiced by most of the people in the country. The rate of poverty is very high in the country and it was estimated that 44 percent of the people living in the country earned below the poverty line (Bureau of Western Hemisphere Affairs 2011). Most of the people in the country live in the urban areas and people leave the rural areas and move to the developed ones in search of better opportunities. Furthermore, many people leave the country and move to the United States for better earning opportunities. The country earns much of its income by sending oil to other countries as it is an oil producing country. Criminal activities are a reason of many problems in the country. The abduction rates in Mexico are marked to be very high in comparison to other countries across the globe. Strong drug trafficking organizati ons function in the country and they are responsible for the drug trading between South America and the United States. Felipe Calderon was declared as the President of the country in the year 2006. He took strong steps for overcoming the issue of drug trafficking and his measures have resulted in the death of 35000 people in the country since the initiation of his campaign against drugs (BBC 2012). Mexico is marked to be a country with a leading role in the making of drugs as well serving as a route for the transportation of drugs. The major movement of drugs which include marijuana and methamphetamine in the United States is from Mexico. Ninety percent of the cocaine that reaches to the United States is through its movement via Mexico. ... The drug trafficking organizations are not only involved in the movement of drugs but at the same time, they are involved in kidnappings as well as murders. The drug cartels have gained a strong hold in the country during the last decade of the twentieth century. This mainly followed the deaths of Cali and Medellin cartels belonging to Colombia. The National Drug Intelligence Center has put forward that the drug trade in the United States is now mainly dominated by the Mexican drug mafia. The Mexican drug cartels have a strong stand and many government officials particularly those from the law enforcement agencies work in collaboration with them. This is owing to the bribes provided by the drug trafficking organizations. A campaign was initiated in the year 2006 by the President of Mexico against the drug cartels in nine states out of the total thirty two states in Mexico (Cook et al 2007). The Mexican government has put forward the fact that there are seven drug cartels working in t he country. Gulf, Sinaloa and Juarez are the major drug trafficking groups and their presence is dominant in most parts of the country. Many dominant drug trafficking organizations have started working together in Mexico. This has led to the formation of two major groups in the world of drug trafficking in Mexico. It has been indicated that this unity has mainly resulted due to the arrest of many leaders in these groups. Mexican cartels have also started to have a strong hold in the United States. They have done so via cultivating drugs on the land of the United States and by forming alliances with criminal groups in the United States. The purpose of this alliance is to make the

Sheila Change during Essay Example for Free

Sheila Change during Essay Sheila was shocked about this, but this was a contrast to between her and the rest of her family; as her family felt no emotion not a surprised or shocked expression in the room. Sheila was so shocked and disgusted about what her mother did she ended up turning on her mother Mother, I think it was cruel and vile. This shows us what Sheila really feels about her mother and she uses strong words against her mothers actions, but if we go back earlier Sheila would never turn on her own mother but because she wants everything to come out and she now see her mother for who she really is. When the inspector told Mrs Birling what she did was completely wrong and what if it happen to her, Sheila was shocked but Mr Birling mind wasnt really on what Mrs Birling did but was on if the press get hold of the situation -The Press might easily take it up-this shows us that Mr Birling takes up his own self interest, this tells us that he is a selfish man, he doesnt care about Eva but cares about the reputation of his family. In the beginning of Act 3 Eric comes in knowing that the family now knows of his drinking problem. It was Sheila that told the family about Eric, this made Eric angry and he feels that Sheila betrayed him You little sneak. This shows us that Sheila was being open about everything not keeping anything a secret which means she is an honest person. It also showed the relationship between Eric and Sheila because this mean the must be very close as the Eric told Sheila his secret trusting Sheila. When Sheila told Eric that she kept the secret for months I could have told her months ago, not of course I didnt. This shows that Sheila as protected Eric and shown loyalty to Eric by not telling their parents. Eric revealed how he came into contact with Eva Smith. Eva and Eric met in a bar and they had a few drinks but they got drunk and Eric insisted to stay with her for the night and that is when they slept with each other. They met again in the same bar and they talked with each other and they slept with each other again. Eric admitted that he wasnt in love with her but he liked her. They met up again and she told Eric that she was pregnant. Eva didnt want to get married because she knew that Eric didnt love her. He realised that Eva didnt have a job so stole some money from small banks his fathers companies had and he gave it to Eva but when Eva discovered the money was stolen so she stopped collecting the money. Eva didnt want to see Eric no more. Eric was wondering how come everyone knew that Eva was pregnant and he asked if Eva told them and Sheila said She told mother. This shows that Sheila is quick to let everything out in the open not letting anyone get away with anything. Eric was furious at his mother telling her that she killed her own grand-child. Before the fight got out of hand the inspector told them all that they all had a part in killing Eva Smith. He told them not to forget it. Telling them what they did exactly and telling Sheila that she didnt start the problem but Birling by not accepting her request. He told them how they all got to look after everyone else. After the speech the inspector leaves, leaving the family in disbelief. The family started again to have disagreements blaming it on each other. But they wonder if the inspector was a real inspector. Sheila says it doesnt matter who he was. The whole point of the inspector coming was to make the family think about their actions. We notice that Sheilas character changes after the inspector leaves. She starts to talk back to her parents, she becomes angry at them (flaring up) this shows us that she as started to stand up to her parents. Sheila tells her parents that they are being Childish. This shows that she has turned the tables on her parents making them see its their fault as well as Erics and hers. Later Gerald had turned up at the Birlings house. Gerald told the Birling family that Inspector Goole doesnt work for the police. This made the family puzzled. Gerald challenged the Birling family asking them is it the same they all saw which may not be true. They may not even know the same girl. The Birling family dont even know if there is an incident today. Mr Birling looks at them triumphantly and puts the theory altogether. They all came up with a conclusion that it was all a hoax. Mr Birling says Im convinced it is. No police inquiry. No one girl that all this happened to. No scandal-Then Sheila says No suicide? this tells us that Sheila is very thankful that there is no death or unborn life on her conscience but the rest of Sheilas family still dont care about Eva Smith, they only care that they is no public scandal. Mr Birling told Sheila that it was all over, Sheila says that everything did really happen but it didnt end in a tragedy so lucky for them she also says -But it might have done This tells us that Sheila is still thinking of what may have happened if there was a girl that died and that they should just make it has a joke. But Mr Birling mocks the fact that a girl might have died and he starts to mimic the inspectors last speech. He tells Sheila to go to bed and she says It frightens me the way you talk. This shows that Sheila is now disagreeing with her family values; she thinks that her family hasnt changed a bit since Inspector Goole was there. Sheila doesnt want a repeat of what happen again, she wants her family to change for the better. Sheila confronts her parents on how they are behaving Youre pretending everythings just as it was before. This is telling us that Sheila is quite upset that her family is pretending that everything is okay but her and Eric learnt their lessons. Unlike the rest of the family Sheila is calm and level-headed. Gerald holds up the ring to Sheila. This is history repeating itself as earlier in the story Gerald gave Sheila a ring announcing their engagement but this time Sheila says No, not yet. Its too soon. I must think. This tells us that she is not ready to step into her old role it also shows that she still doesnt agree with her family value and she knows her as to think about her this time and know what she wants instead of her parents pushing her to marry Gerald someone rich and of high class. So she turns Gerald down. In the beginning we portrayed Sheila as a very superficial person who was only knows the obvious. She is also a selfish and self-centred person like when she went to Milward only thinking about herself she got Eva Smith sacked from her she also said I couldnt be sorry for her. She heard that she got sacked and she showed no care for other people but herself. She was also an immature, childish and naive person. Sheila was at the bottom of the family which meant she was to answer if she was spoken to. She abused her status to get what she wanted like at Milward where she said she would persuade her mother to close the account they have with Milward unless they sack the girl. She is also a spoilt and inconsiderate person; she can get what she wants if she just uses the power that she has of an upper class citizen. We could see that she was very detached from reality; she didnt know what was going on in the outside world where there were people from the lower class and working class. Sheila doesnt really speak for herself You talk as of we are responsible- Then Birling says (cutting in) Just a minute Sheila This shows that her father wont really allow her to express her own point of view. As we come to the end of the story Sheilas character changes dramatically as she finds out who else was responsible for Eva Smiths suicidal death. Sheila is an independent and takes responsibilities of her actions I know. I had her turned out of a job. I started it. Sheila is willing to take part of the responsibilities of the death of Eva Smith. She is also a changed woman You and I arent the same people who sat down to dinner here this also shows that she know as well that she is a changed woman. She is also very perceptive and inquisitive she is knows what her mother had done before her mother admitted and she is very inquisitive saying to the inspector I dont understand about you. Sheila now also listens to her conscience knowing when Eva was said not to be true she had no death on her conscience but she still felt that the story was really and that there was an Eva Smith. She is an honest deep thinker who thinks about the consequences of her actions on the day of Milward and how that led on to other unfortunate events. Sheila is not anymore as heartless as the others but she is sensitive she doesnt listen to the rest of her family when they say that the inspector was hoax and when they said that there was no suicide Youre pretending like everythings just as it was before. The rest of Sheilas family act like the inspector coming was a dream but Sheila isnt. Sheila is critical of family values she doesnt believe that the family can use their position in a manner that is not useful to other people around them. Finally, she is unwilling to revert to her pervious self; Sheila says to her family Youre ready to go on in the same old way. And Mr Birling says (Amused) and youre not, eh? Sheila says No, because I remember what he said, how he looked and what he made me feel. This is saying that she as learnt a lot from the inspector and she is never going to return to her old self. Sheila even rejects the ring offered back by Gerald because she knows that she is not ready yet and she needs to think. .

Pharmacists Role in Complementary Alternative Medicines

Pharmacists Role in Complementary Alternative Medicines Pharmacists Role in Complementary Alternative Medicines The first section of this paper will provide background information on the use of complementary and alternative medicines (CAMs) and their associated risks and benefits. Additionally, information on the pharmacists’ role in CAMs and services in their pharmacies will be discussed. Next, the theory that potential ethical conflicts arise for pharmacists between keeping the health and wellbeing of clients and the community as their primary concern versus the prospect of turning a profit will be considered. Before concluding, other important ethical issues including duty of care, and liability will be discussed. Background The term CAM refers to any healing practise that doesn’t fall under the heading of conventional medicine. It encompasses not just pharmaceutical preparations, but diet, and traditional forms of health care including acupuncture, Chinese medicine, homeopathy, etc.1 In the past, people who sold CAMs were sometimes referred to as quacks, or someone who promotes unsupported methods that lack scientifically credible rational.2 CAMs were regarded as old wives tails, and their claims dismissed by the medical community.3   More recently CAMs have become a prominent feature in today’s health care regimens. In 2000 according to the Therapeutic Goods Administration (TGA) 52 percent of Australians were using at least one non-prescribed complementary medicine.4 The Therapeutic Goods Act of 1989 effectively legitimised CAMs by allowing them to be entered into the Australian Register of Therapeutic Goods (ARTG) as a listed medicine. They have to meet a lesser set of standards than conventional medicines, which is one of the major concerns of allopathic practioners.5 With the passing of this act, pharmacies could legitimately sell two types of products; medicines for which there is scientific evidence   (prescription and over the counter products) and unproven medications (some CAMs) that may lack efficacy.   There are many risks associated with using CAMS including direct risks, substitutions made, nonprofessional advice received, and unreliable diagnostic tests.6 In some cases, CAMs have caused serious harm. The adverse effects range from infection due to dirty acupuncture needles, altering the effectiveness of other pharmacologically proven agents, to death from chiropractic manipulation. Substitutions pose a great risk for serious conditions. Replacing conventional treatments with CAMs can lead to many adverse effects. For example, treating melanoma with a herbal ointment rather than surgery, radiotherapy, or chemotherapy can have disastrous consequences. Some patients, especially those with life threatening illnesses, will try anything to improve their symptoms. Some CAM practitioners take advantage of this and recommend treatments that are very costly and at the expense of other proven treatments. Unproven tests include, but aren’t limited to, reflexology and electro-dermal t esting.6 The danger in this type of testing is the high likelihood of misdiagnosis.   Despite the large body of evidence in the scientific community of the poor efficacy of CAMs, there is some evidence for their use as seen in cranberry for urinary tract infections St. John’s Wart for depression and a variety of others.7 In 1993 Australians spent an estimated 1 billion dollars on CAMs and by 2000 that number had risen to 2.3 billion.8   Shockingly, only 57 percent of Australians reported or discussed the use of these products to their doctors.9 The potential dangers outlined above and these statistics show the need for a pharmacists intervention. Pharmacist’s Role Pharmacists are a vital part of the allopathic health care team, often being the first port of call for patients requesting CAMs.10   The community pharmacy is an ideal environment to deliver quality, cost effective, and professional services to the general public. Patient’s safety and access to this high quality care is of paramount importance.11 Pharmacists counsel life style choices, recommend an appropriate non-prescription medication, or refer patient’s to a physician to improve outcomes.12      When responding to enquiries about CAMs pharmacists need to consider a variety of issues. The customers’ cultural and social beliefs and desire to take control of their own treatment should be viewed non-judgementally. Pharmacists need to stay up to date, and be aware of evidence to support the use of different products. Information about CAMs should be provided on an evidence-based level so the most accurate information is delivered to the patient. Pharmacist s also need to be aware of potential interactions with conventional products, and report adverse drug reactions to both the Adverse Drug Reaction’s Committee and the product’s sponsor.7 Furthermore, pharmacists must remind patients that CAMs are medications and should be openly discussed so potential interactions and side effects can be identified. Ethics and profit In a 2005 study of 484 community pharmacists in New South Wales 77% of respondents personally used CAMs and said that they offered CAM products for sale in their pharmacies. A majority of the pharmacists believed CAMs enhanced customers’ image of the pharmacy and 87% reported they increased customer numbers and annual sales.13 From these results it is evident that a potential conflict between promoting and selling CAMs and ethics could arise. Pharmacists are intrinsically placed in an ethical dilemma daily. They have dual roles as health care providers and businesspeople. As health care professionals they are expected to provide a high level of unbiased health care, while their business side is expected to sell products and generate a profit. Professional and business roles are generally believed to be in conflict with each other and roles are traditionally viewed as being exclusive. According to Chappell et al community pharmacists are one of the few occupations where professional and business values co-exist.   They found no correlation between the value placed on business and the level of care or â€Å"professionalism† displayed by the pharmacists. This suggests pharmacists are able to act dually as a salesperson but still deliver professional information.14 The degree of professionalism has been called into question by Kennedy et al. They demonstrated that in some cases pharmacists, especially proprietors, sometimes recommend more expensive products when a cheaper generic version is available, but the overall outcome was satisfactory. All pharmacists recommended an appropriate treatment for the condition but the product selected differed among owners and employee pharmacists. Although the patient received a high level of care, the fact that he or she had a cheaper option calls the level of professionalism into question.  Ã‚  Ã‚   Further evidence for professionalism is seen in a study by Perepelkin et al. where they found pharmacists, regardless of their ownership structure, are professionally oriented in their practise. The difference in services provided was only seen in terms of professional autonomy, decision-making and amount of control. There was no difference in the amount of profit-driven goals between the groups.16 Similarly, in a recent study, Kronus found that pharmacists, regardless of their role orientations (business versus professional), were similarly motivated by service and income values. She suggested that the theoretical model suggesting that business is based on extrinsic values and professionalism is based on altruistic values should be revised when talking about pharmacy. She found altruism (professionalism) was the dominant factor in the field of pharmacy. Since most pharmacists are salaried employees there is little pressure to increase profit by pushing CAMs with no supporting evidence. It would be very easy to jump to the conclusion that the need to make a profit would in some way have a negative effect on pharmacy owners or employed pharmacists (reward systems) to act as independent ethical health care providers when CAMs are viewed as huge profit generators.17 Wingfield et al suggest that ‘ethics is so integrated and intrinsic to daily practise that there is no need to single ethical issues for special attention,’ as demonstrated by a lack of a journal dedicated to pharmacy ethics (there are ethical journals for medicine and nursing). Rather the ethical behaviour of the pharmacist is displayed in all aspects of daily practise culling the drive for profits.18 In Australia the behaviour of pharmacists is guided by the Pharmaceutical Society of Australia’s Code of Professional Conduct (PSACPC).7 Pharmacists sell CAMs in pharmacies that does give credibility to CAMs and to some extent promote their usage.   Also, pharmacists are in a unique position to influence the sale of certain products. For example, CAMs are used by 60 to 80% of oncology patients. According to the British Columbia Cancer Society the psychosocial needs of patients including ‘increased anxiety, need for information, maintenance of a sense of hope, a sense of control, negative experience with conventional medicine, and perceived holistic nature of complementary medicine,’ is the reason for the high percent of people using the medicine and not the availability of the product in pharmacies.19 Pharmacists don’t need to promote these products as psychosocial needs are very powerful and patients are clamouring for these medications in increasing numbers. Although the pharmacy is a business, business objectives wouldn’t necessarily suffer, as knowledgeable and honest patient counselli ng plays an important role in customer satisfaction and thus profitability. An unsatisfied customer would certainly seek another pharmacy.20 These satisfied customers will keep coming back to the pharmacy not just for CAMs but for prescription and personal products as well. This is a win-win situation for both the customer and the pharmacist who now has the opportunity to play an active role in the health of the patient as well as make a decent living. It is the pharmacist who provides the factual advice for patients who seek out these products. Through professionalism this temptation to take advantage of this behaviour is easily removed. Pharmacists develop close relationships with their customers by taking time to talk about medications. Professional orientation happens because patient counselling of all medications including CAMs is at the cornerstone of ethical pharmacy practice and high quality care. As previously stated, the pharmacist’s role in counselling in the use o f CAMs is the most effective in ensuring the health and safety of patients.   When counselling patients, pharmacists follow the PSACPC. By following the PSACPC pharmacists remain in the scope of their practice, are covered for malpractice liability for negligent care and for informed consent issues, and foremost, ensure the health and well-being of clients and the Australian community. Under the 9 key principles of PSACPC, counselling advice for CAM usage is about adhering to the principles of evidence based medicine and critically examining and honestly informing patients of unproven medications and therapies. Pharmacists must also respect the beliefs and judgements of patients and other health professionals while regarding the patient’s autonomy to make decisions regarding their own treatment but at the same time offering guidance and advice based on evidence-based information.21  Ã‚   Thus, when a pharmacist gives advice on the use of Cams based on PSACPC guidelines after considering clinical and patient factors there may be commercial benefits but they do not necessarily compromise the quality of the recommendations. In pharmacy, ethics and profit can and do exist without conflict in the sale of all products.   Duty of care regarding informed consent As outlined above a majority number of Australians are using and want to use CAMs. It is therefore the duty of pharmacists to discuss these treatments with their patients.22 A study in the US found almost three-quarters of the pharmacists surveyed worked in stores where herbal medicines were sold.23 Almost half of the pharmacists agreed with the statement, ‘herbal medicines are not accepted by the majority of my colleagues’ and only a quarter agreed with the statement ‘herbs are efficacious’.24 25 It can be seen that most pharmacists don’t believe in the products so recommending them is difficult. But, they have an ethical obligation to adhere to the PSACPC and respect the autonomy and dignity of the patient to make informed decisions.21 Once the pharmacist has disclosed and openly discussed the different treatment options his or her ethical obligation has been fulfilled. In the United States this is taken one step further.   It is a legal obligatio n for practioners to disclose information for CAMs if they are generally accepted within the medical community. Failure to do so can result in legal action.26 Liability in referring to CAMs Liability issues are new territory for pharmacists recommending CAMs to patients. Homeopathy, for example, is completely contradictory to the principles of modern pharmacology. The incompatibility of homeopathic paradigms with all of basic science must be taken into consideration.22   Keeping in line with the PSACPC, pharmacists cannot ethically recommend a product or service to which they know there is no evidence to support its use, and is not in the best interest in the health and well being of the patient or community. In Canada, The Pharmacy Code of Ethics requires pharmacists to never knowingly provide any products which are not good quality.27   In the United States medical practitioners can be held liable for referring patients to a CAM practitioner if they â€Å"should have known† the CAM practitioner might be â€Å"incompetent†. This shows that medical professionals are not just ethically but legally responsible for protecting patients from inferior medical treatments.28 CAM practitioners argue that their treatments are holistic and some of the therapeutic benefits are unmeasurable. Because western medicine supports evidence based on quantifiable outcomes the two doctrines of practise often clash. It is very difficult to compare the s piritual healing power of CAMs to the physical healing of western medicine.28 As long as the CAM treatment is not interfering with a patient’s level of care, there is no reason to discredit a potential treatment that may make a patient ‘feel’ better. An honest answer to the efficacy of a specific CAM and reporting that some people say it makes them feel better is the best course of action.     Further compounding the issue is the training level of the CAM providers. Most are not ‘health care professionals’ and have inadequate understating of biology, pharmacology, patho-physiology, and other sciences that govern western medicine. Since pharmacists cannot ethically refer a patient for a treatment that they believe may affect their health or wellbeing the ethical dilemma of whether to recommend this option is exacerbated. Although, a recent Canadian study reported only 2% of pharmacists felt they had adequate information about complementary and alternative health care, they are still better suited than CAMs to provide information on the prodcuts.10 A pharmacists guidance is based on principles 1 and 8 of the (PSACPC), advising patient of the scientific evidence available while still respecting their autonomy.28 Where CAM providers have no such code of ethics. Conclusion This paper examined the background issues associated with complementary and alternative medicines (CAMs) and the associated risks and benefits that go along with them. Additionally, the pharmacists’ role in providing CAMs was discussed. The many ethical issues, including profit, although seemingly complex can and should be negotiated using the PSACPC guidelines. The introduction and sale of CAMs have not changed the pharmacist’s code of ethics where the patient’s well-being and health remains the focus. As CAMs are becoming more popular and accepted by the public, pharmacists need to have a high level of understanding of the many issues associated with them. The ethical issues pharmacists face daily are apparently being handled appropriately according the literature cited, and based on the public’s perception of pharmacists being one of the most trusted health professionals.

American Views on Sexuality

American Views on Sexuality (Jump to) Introduction Discussion Americans’ Contacts with Homosexuals LGBT Americans Opinions Social Acceptance by American Society Religious Belief References INTRODUCTION Being a bisexual means getting attracted to both people of their own gender and another gender also. Women who get attracted to the female gender are known as lesbians and similarly the men who get attracted to the male gender are known as gay. The bisexual women and men get attracted to both the male and the female gender. Getting attracted to the same gender is also known as homosexuality. The attitudes towards the homosexuality differ in different cultures, because all the cultures have their own values regarding sexuality. Some countries approve the homosexual behavior whereas some disapproves it. The research has been done and it is found that the certain populations have accepted the homosexuality more than others. Homosexuality may be illegal in some countries, but where it is legal, there a age has been defined and that age differs from country to country. Homosexuality is neither a mental illness not a matter of an individual’s choice. It does not threaten the healthy and secure homosexuals. Therefore, there is no need to oppress the homosexuality. But in our society, discrimination occurs daily against gays, lesbians and bisexual people which greatly affect them (Gay, Lesbian and Bisexual Issues). Due to which the gay, lesbian and the bisexual people feel depression and the relationship problems same as the heterosexual people feel. DISCUSSION I agree with your statement, as in my opinion also, being a lesbian or bisexual woman is more accepted than being a gay or bisexual man by the current American society. A research has been done and it has been found out that the most Americans don’t bother while getting surrounded by the homosexuals. Various studies has been done and results into various factors, such as: 82% of the Americans don’t bother when around homosexuals (Views of Gay Man and Lesbians, Roots of Homosexuality, Personal Contacts with Gays, 2013). Whereas, 14% of the Americans say that, it bothers them while surrounded by homosexuals. In 2003, about 76% of the Americans do not bother to be around homosexuals. Few years ago, the balance between the gay and the lesbians was not favorable. As: Gay men were viewed favorable only by the 37 % of the Americans, whereas 51% of the Americans viewed them as unfavorably. Lesbian women were viewed favorable only by the 39 % of the Americans, whereas 48% of the Americans viewed them as unfavorably. By a 2 % margin, the American people are more favorable to lesbian women than gay men. But today, 58% of the American people view the lesbian women favorably while only 29% of the Americans view them as unfavorably. And, 55% to 32% margins (Views of Gay Man and Lesbians, Roots of Homosexuality, Personal Contacts with Gays, 2013) have favorable views towards gay men than unfavorable views. Still, the percentages of Americans who have the favorable views towards lesbian women are more than the ones who have favorable views towards the gay men. The study has found out that the Americans’ views are rapidly changes to acceptance of gay men and lesbian women with time (Harms, 2011). Americans now approve the same-sex relations and moreover, they provide the lesbians and gays the freedom of expression. Moreover, public have different views about the fact that why people are lesbian and gay? And, about 42% of the public thinks that the people choose themselves to live as gay or lesbian. About 8% thinks that it’s a result of upbringing, due to which the people are gay or lesbian, and Others think that they are born as lesbian or gay. In American society, about 66% of the Americans think that the people choose themselves to live as gay or lesbian. About 20% of the Americans think that they are born as lesbian or gay. But overall, 58% of the people thinks that the homosexuality should be accepted as they thinks that its by birth, and 63% of the people think that it should not be accepted as they thinks that it’s just a choice of people of being gay or lesbian. Americans’ Contacts with Homosexuals In Americans Society, different people have different views to share about their contacts with the homosexuals. And, 87% of the Americans are somehow in contacts with ones who are lesbian or gay. 23% of the Americans say that they know personally some people who are gay or lesbian. 61% of the Americans had gay or lesbian contacts (Views of Gay Man and Lesbians, Roots of Homosexuality, Personal Contacts with Gays, 2013). The contacts with gays and lesbians also differ in different religions. As 30 % of the religions say that they know some gays and lesbians, and Only 8 % says that they don’t know any. LGBT Americans Opinions Lesbians, Gays, Bisexuals and Transgender (LGBT) adults are asked the question and it has been found out that the society is accepting them as compared to past decades and more will accept it in upcoming decades (A Survey of LGBT Americans, 2013). And, 39% of the LGBT Americans say that they are not accepted by their families. 30% of the LGBT Americans say that they are attacked physically. 29% of the LGBT Americans say that they are not allowed to go at worship places. 21% of the LGBT Americans say that they are not treated fairly by their employees. 21% of the LGBT Americans say that they are the targets of jokes. Moreover, At the age of 17, the people gets the feel that they are homosexual, and at the age of 20, they share this information with their families. LGBT adults say that their acceptance is increasing as the time passes. But some of LGBT adults say that they still feels discrimination in the society. They said that they need more acceptance in mostly all the societies. Thus, their views needs to be focused on. Social Acceptance by American Society Most of the LGBT adults have said that they have got social acceptance and moreover, there is significant progress towards the social acceptance of LGBT adults. The study has been done to see the criteria of social acceptance. And 19% says that there is progress towards social acceptance of LGBT adults. 59% says that there is some (A Survey of LGBT Americans, 2013), and 21% says that there is no progress in socially accepting the LGBT adults. Lesbians, Gays, Bisexuals and Transgender (LGBT) adults are more accepted by the American society as compared to past and others socities. But, still a more acceptance is needed, so that they don’t feel any discrimination. According to some LGBT adults, they are accepted by most of the American society whereas some LGBT adults said that they need more acceptance in the American Society as they feel discriminants. The views of different LGBT adults are needs to kept in perspective. In compared to all other socities, Americans are found to be ore tolerant towards the lesbians, Gays, Bisexuals and Transgender (LGBT) adults than they al were in past decades. Only 2 out of 10 said they are not socially accepted as they are treated unfairly by the public, they are not either accepted by their own families, they are physically attacked, and moreover, they are the target of jokes. Religious Belief In opposition to the social acceptance of LGBT adults, Religious belief is an important factor (Religious Belief and Views of Homosexuality, 2013). Over the past decades, 47% to 60% of the Americans belief that the homosexuality should be accepted. While only 45% to 31 % of the Americans think that it should not be accepted. When the Americans who think that the homosexuality should not be accepted are asked why they feel so? Then 52% of them said that, homosexuality is against their religion. As Religion is a big factor, due to which some Americans are against the homosexuality. Moreover, they belief that the homosexuality is traditionally wrong. But, there is only small percentage of Americans who think that the homosexuality is against their religion. 58% of the Americans say that the homosexuality should br accepted by the alw and should be legal according to the laws. They said, it should be supported same as the traditional relations are supported. Thus, It has been notices that the lesbians are more accepted than gays in American Society, But overall, their acceptance in this society has been progressed. REFERENCES A Survey of LGBT Americans. (2013, June 13). Retrieved November 5, 2014, from http://www.pewsocialtrends.org: http://www.pewsocialtrends.org/2013/06/13/a-survey-of-lgbt-americans/# Gay, Lesbian and Bisexual Issues. (n.d.). Retrieved November 5, 2014, from http://cms.bsu.edu: http://cms.bsu.edu/campuslife/counselingcenter/newsfooteritems/diversityresources/diversityinformationandlinks/glbt Harms, W. (2011, October 5). US VIEWS ON GAYS, LESBIANS SHIFT SHARPLY. Retrieved November 5, 2014, from http://www.futurity.org: http://www.futurity.org/us-views-on-gays-lesbians-shift-sharply/ Religious Belief and Views of Homosexuality. (2013, June 6). Retrieved November 5, 2014, from http://www.people-press.org: http://www.people-press.org/2013/06/06/section-3-religious-belief-and-views-of-homosexuality/ Views of Gay Man and Lesbians, Roots of Homosexuality, Personal Contacts with Gays. (2013, June 6). Retrieved November 5, 2014, from http://www.people-press.org: http://www.people-press.org/2013/06/06/section-2-views-of-gay-men-and-lesbians-roots-of-homosexuality-personal-contact-with-gays/

Attention Deficit Hyperactivity Disorder (ADHD) Essay -- Health, Menta

Attention Deficit Hyperactivity Disorder (ADHD) Introduction Among the behavioural disorders that are commonly diagnosed, Attention Deficit Hyperactivity Disorder (ADHD) is the most prevalent among youth and children. It is a persistent disorder that is attributed to neurobehavioral problems. About 3%-5% of all the children in America are affected by ADHD (NINDS Attention Deficit-Hyperactivity Disorder Information Page, 2011). The disorder is characterized by inability to concentrate or focus on a task and exercise behavioural inhibition that is normally related to age. There are several warning signs which can indicate the possibility that a child may be affected by the disorder. These include difficulties adhering to instructions, talking a lot, disorganization, leaving homework or other chores unfinished, and having problems paying attention to details or responding (NINDS Attention Deficit-Hyperactivity Disorder Information Page, 2011). The fact that the disorder is considerably prevalent and costly has prompted research efforts in finding treatment and management approaches for ADHD. The research into this mental illness has been largely inspired by findings regarding its physiological basis which has paved way for discovering treatment approaches. It is imperative for those taking care of children affected with ADHD to understand the diagnosis, prognosis and phenomenology of ADHD so as to provide quality care for the affected (Sefa, 2007). In this paper, the physiological basis as well as the symptoms of ADHD will be discussed. In addition, the paper will discuss a biological approach to ADHD treatment and compare and contrast the genetic and environmental influences of the disorder. Finally, a summary of two articles reg... ...n From the above discussion, ADHD is a mental illness that not only affects children but also adults. It is characterized by hyperactivity, impulsivity, disorganization, and inability to focus and complete tasks without being distracted. In order to unravel the physiological basis of ADHD, research has targeted neurobiological and neurochemical aberrances notable in individuals with ADHD. The use of psychostimulants in the treatment of ADHD alters the functioning of the brain by enhancing attention through increasing blood flow in the frontal lobe areas. Current treatment trends emphasize the use of a multimodal approach so as to comprehensively address the complex nature of ADHD. From the discussion, ADHD is seen to be influenced in a significant way by both genetic and environmental factors. Genetic research has focused on twin studies and familial studies.

Fate is to Blame for the Deaths of the Main Characters of Romeo and Juliet by William Shakespeare :: Shakespeare, Romeo and Juliet

In this essay I am going to discuss who is responsible for the tragic ending of the play, by talking about how each character interacts with the one that dies and see if any of their actions could have resulted in the death of the main characters. During the essay I am going to eliminate characters that I think did not influence people enough to resort in the killings from my list below, whether it was Romeo, Juliet, Tybalt, Friar Lawrence, the Nurse, both the feuding families, Fate or other influential characters including the writer, Shakespeare himself. At the end I will draw a conclusion of who I think is most to blame for the deaths at the end of the play, although I do think each person added their own little bit to the cause, and explain why to answer the initial question that I was set. Romeo and Juliet is a tragedy about two feuding families and the children from each house that meet and fall madly in love but are forbidden to be together. Within the language Shakespeare uses a lot of technical terms that also describe the thoughts and feelings of the main people. For example oxymora is used a lot when Romeo is describing his love for Rosaline and Juliet, ?O brawling love, o loving hate? as the opposites show he is confused and resembles the two family?s conflicts. It also shows that love has pros and cons as does everything in life, which is an example of dramatic irony as Romeo doesn?t realise how true it?s going to be. This also helps us understand the dramatic effects of the language. Fate is talked about a lot too, which adds to the dramatic features of the play, so as the story evolves everything the characters say can relate back to the prologue in some way when we find out what is going to happen in the end. The quote ?From forth the fatal loins of these two foes? shows that nothing good will happen as fatal means almost deathly and both the families children end up dying at the end. Also in the prologue ?The fearful passage of their death-marked love? means they are fated to die because they are in love through a course of unfortunate events. Also at the Capulets? party when Romeo and Juliet first kiss the rest of the play is almost set out for you.

Thermodynamic Analysis and Performance Characteristics

AEROSPACE ENGINEERING SCHOOL OF MECHANICAL ENGINEERING AND DESIGN THE THERMODYNAMIC ANALYSIS AND PERFORMANCE CHARACTRISTICS OF A TURBOFAN JET ENGINE By J. E, Ibok 2011 Supervisor: Dr Lionel Ganippa ABSTRACT This work focuses on the performance analysis of a twin spool mixed flow turbofan engine. The main objective was to investigate the effects of using hydrogen, kerosene and natural gas fuel on the performance characteristics such as net thrust, specific fuel consumption and propulsive efficiency of the turbofan.Another aim of this work was to introduce the concept of exergy and thermoeconomics analysis for twin spool mixed flow turbofan engine and show the components that contributes the most to the inefficiency of the engine. A generic simulation was carried out using Gas Turb 11 software to obtain reasonable analysis results that were verified with a real-time JT8D-15A turbofan engine. The parametric analysis was done for constant value of mass flow rate of fuel and constant turb ine inlet temperature for all three fuels.The result were rightfully obtained for these analysis cases and discussed accordingly. Brunel University Mechanical Engineering Academic Session: 2010/2011 Name of Student: Johnson Essien Ibok Supervisor:Dr Lionel Ganippa Title: The Performance Characteristics and Thermodynamics Exergy and Thermoeconomics analysis of a Twin Spool Mixed Flow Turbofan Engine Operating at 30,000ft at M0 0. using Kerosene, natural Gas and Hydrogen Fuel. Abstract: This work focuses on the performance analysis of a twin spool mixed flow turbofan engine. A generic simulation was carried out using Gas Turb 11 software to obtain reasonable analysis results that were verified with a real-time JT8D-15A turbofan engine. The parametric analysis was done for constant value of mass flow rate of fuel and constant turbine inlet temperature for all three fuels.The result were rightfully obtained for these analysis cases and discussed accordingly. Objectives: The main aim of this work is to conduct the parametric cycle simulation of a twin spool mixed flow turbofan engine and investigate the performance characteristics of it. Another aim of this work is to show the effects of using hydrogen, Kerosene and natural gas fuel on the overall performance of the twin spool mixed flow turbofan engine.Also, the purpose of this work is to introduce the use of the second law of thermodynamics analysis known as exergy and thermoeconomics in analysis the twin spool mixed flow turbofan engine Background/Applications: This work is applicable in so many ways when it comes to the overall performance optimization and feasibility analysis of a jet engine. This work relates to the aerospace and aviation industries since the turbofan engine is amongst the vast number of jet engine used in propulsion of aircrafts.There is increasing pressure in the aviation industry to reduce pollution and depletion of energy resources while at the same time maintaining reasonable investment cost and high overall performance. Hence, this research was conducted in hopes of coming up with a new solution to this problem. Conclusions: The main conclusion drawn from the performance analysis is that hydrogen fuel produced the highest thrust level and the lowest specific fuel consumption between the three fuels for a constant mass flow rate of fuel.Kerosene fuel generated thrust level can be increased if it is mixed with a small amount of hydrogen. The Exit jet velocity ratio remained constant despite the increasing bypass ratio for all three fuels at constant mass flow rate of fuel. Using the exergetic analysis showed that the combustion chamber and the mixer contributed the most to the inefficiency of the turbofan engine. The amount of exergy transferred into the turbofan engine by hydrogen was depleted in the smallest ratio compared to natural gas and kerosene for constant mass flow rate of fuel.The thermoeconomics analysis showed that it is preferable to use local based co st evaluation to quantity specific thermoeconomics cost of thrust than the global method since the value was lower. Results: The results obtained from the simulation using Gas Turb 11 produced an error range of 0. 25% – 8. 5% when verified with the actual test data of the JT8D-15A turbofan engine. The results obtained for the analysis defined a reference design point at which the parametric analysis was conducted on. The analysis was done in three cases as shown clearly in the test matrix in table 1 below.Analysis| Parameters being varied| Parameters Kept Constant| Performance Characteristics| case 1| * Bypass ratio * Turbine Inlet temperature| * HPC Pressure Ratio * LPC Pressure Ratio * Fan Pressure Ratio| * Velocity ratio * Fuel-Air-ratio * Turbine inlet temperature * Net thrust * Specific Fuel Consumption * Thermal efficiency * Propulsive efficiency| case 2| * Bypass Ratio * Three different fuelsmH2mCH4mC12H23| * Mass flow rate of fuel * HPC Pressure Ratio * LPC Pressure R atio * Fan Pressure Ratio| | Case 3| * Bypass Ratio * Three different fuelsmH2mCH4mC12H23| * Turbine inlet temperature * HPC Pressure Ratio * LPC Pressure Ratio * Fan Pressure Ratio| | Table 1 The Test matrix of the Parametric Analysis. The exergy analysis was done for the parametric analysis of case 2 and case 3 where the exergy destruction rates, exergetic efficiency, exergy improvement potential rate and fuel depletion ratio were calculated. The distribution of these results throughout each component of the turbofan engine was represented with bar charts and Grassmann diagram. The thermoeconomics analysis was conducted for analysis case 2 using kerosene fuel.The specific thermoeconomics cost of thrust was calculated using global and local based cost evaluation methods. ACKNOWLEDGEMENTS First of all, I would like to thank my parents for their financial support and encouragement because without them I would not be here and be able to do this work. I am deeply thankful to my supervi sor, Dr Lionel Ganippa for believing in me and giving me the opportunity to work with him in this field of study. I am also thankful to him for giving the necessary guidance and advice and his enthusiasm and innovative ideas inspired me. Finally, I would like to thank Mr Joachim Kurzke for providing me with the necessary software needed for my dissertation. Table of ContentsAcknowledgements i Contents ii List of Notations and Subscripts iv List of Tables vi List of Figures vi Chapter 1: Introduction1 1. 1. Aims and Objectives2 1. 2. Computational Modeling3 Chapter 2: Jet Engines4 2. 1. Performance characteristics4 2. 1. 1. Thrust4 2. 1. 2. Thermal Efficiency5 2. 1. 3. Propulsive efficiency5 2. 1. 4. Overall efficiency6 2. 1. 5. Specific Fuel Consumption6 2. 2. Fuel and Propellants For Jet Engines7 Chapter 3: Turbofan Jet Engines †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦ †¦8 3. 1. Introduction 8 3. 2. Classification of Turbofan Engines9 3. 3. Major Components of a Turbofan Engine10 3. 3. 1. Diffuser10 3. 3. 2. Fan and Compressor11 3. 3. 3. Combustion Chamber12 3. 3. 4. Turbine13 3. 3. 5. Exhaust Nozzle14 3. 4.Thermodynamic Process and Cycle of a Twin Spool Mixed Flow Turbofan Engine15 Chapter 4: Mathematical and Gas turb 11 Modeling of the turbofan Engine18 4. 1. Station Numbering and Assumptions18 4. 2. Design Point Cycle Simulation of the Turbofan Engine18 4. 3. Off-design Point Cycle Simulation of the Turbofan Engine21 4. 3. 1. Module/Component Matching 22 4. 3. 2. Off-Design Point Component Modeling22 Chapter 5: Methodology, Results and Discussions26 5. 1. General Relationship equations of the Major Parameters27 5. 2. Results and Discussions of Parametric cycle Analysis of Case 129 5. 3. Results and Discussions of Parametric Cycle Analysis of Case 235 5. 4.Results and Discussions of Parametric Cycle Analysis of Case 343 Chap ter 6: Exergy and Thermoeconomics Analysis of the Turbofan Engine49 6. 1. Exergy Analysis49 6. 1. 1. Exergy Analysis Modeling 50 6. 1. 2. Exergy and Energy Balance Equations of the Components58 6. 1. 3. General Relationships in Exergetic Analysis of the Turbofan Engine60 6. 1. 4. Results and Discussions61 6. 1. 5. Grassmann Diagram72 6. 2. Thermoeconomics Analysis74 6. 2. 1. Thermoeconomics Analysis Modelling74 6. 2. 2. Global Based Cost Evaluation76 6. 2. 3. Local Based Cost Evaluation77 6. 2. 4. Results and Discussion of the Thermoeconomics Analysis78 Chapter 7 Conclusions and Future Work80 Reference Appendix A Exergy Analysis Results Appendix B Thermoeconomics Analysis resultsList of Notations and Units ?| Isentropic efficiency| ?| Total Pressure ratio| m| Mass Flow Rate (kg/s)| f| Fuel/Air Ratio| M| Mach Number| Pt| Total pressure (kPa)| Tt| Total Temperature (K)| NCV| Net Calorific Value (MJ/kg)| Ht| Total Enthalpy (kJ/kg)| V| Velocity (m/s)| ?| Bypass Ratio| T| Static Temperat ure (K)| P| Static Pressure (kPa)| N| Actual Spool Speed (RPM)| Nc| Corrected Spool Speed (RPM)| mc| Corrected Mass Flow Rate (kg/s)| R| Universal Gas Constant (kJ/kmolK)| ?0| Standard Chemical Exergy (kJ/kmol)| Ex| Exergy Rate (MW)| xi| Mole Fraction| cp| Specific Heat at Constant Pressure (kJ/kgK)| ?| Ratio of Chemical Exergy to NCV| ?| Exergetic Efficiency| | Fuel Depletion Ratio| W| Power Rate of Work done (MW)| List of Subscripts| | LPT| Low Pressure Turbine| HPT| High Pressure Turbine| CC| Combustion Chamber| HPC| High Pressure Compressor| LPC| Low Pressure Compressor| d| Diffuser| noz| Nozzle| mix| Mixer| dest| Destruction Rate| 0, ambFAR| Ambient conditionFuel-Air-Ratio| CH| Chemical| PH| Physical| KN| Kinetic| PN| Potential| IP| Exergy Improvement Potential Rate (MW)| CRF| Cost Recovery Factor| c| Specific Thermoeconomic Cost (MJ/kg)| STD| Standard Temperature and Pressure| TIT| Turbine Inlet Temperature| TSFC| Thrust Specific Fuel Consumption (g/kNs)| SFC| Specific Fuel Co nsumption| p| Propulsive| TH| Thermal|O| Overall| T| Thrust| equip| Equipment| PEC| Capital Cost of Equipment| List of Tables Table 1 input parameters for Design Point Cycle Simulation on Gas Turb 1119 Table 2 Comparison table for the Actual Test Data and Simulated Data using gas Turb 1121 Table 3 Comparison Table for Actual Test Data and Simulated Off-Design Point data Using gas Turb 11. 25 Table 4 Equivalence Ratio of the three Fuels Combustion Processes†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦ 62 Table 5 Assumed Capital costs of Each Component of the Turbofan Engine. 75 Table 6 Flow of Specific Thermoeconomics Cost in all the Components 79 List of Figures Figure 1 Classification of Turbofan Engine9Figure 2 Layout of Forward Fan Twin Spool Mixed Flow Turbofan16 Figure 3 T-S Diagram for the Forward Fan Twin Spool Mixed Flow Turbofan17 Figure 4 Design Point Cycle Simulation Algorithm Using Gas Turb 1120 Figure 5 Example of a Compressor Performance Map/Cu rve24 Figure 6 Effects of Varying Bypass Ratio at Constant Values of TIT on Fuel-Air-Ratio30 Figure 7 Effects of Varying Bypass Ratio at Constant Values of TIT on Exit Velocity Ratio30 Figure 8 Effects of Varying Bypass Ratio at Constant Values of TIT on LPT Exit Pressure Ratio31 Figure 9 Effects of Varying Bypass Ratio at Constant Values of TIT on Net Thrust32 Figure 10 Effects of Varying Bypass Ratio at Constant Values of TIT on Specific Fuel Consumption33 Figure 11 Effects of Varying Bypass Ratio at Constant Values of TIT on Propulsive Efficiency34 Figure 12 Effects of Varying Bypass Ratio t Constant Values of TIT on Thermal Efficiency35 Figure 13 T-S diagram of using Hydrogen Fuel when the bypass Ratio is increased36 Figure 14 Variation of Fuel-Air-Ratio with Bypass Ratio at Constant Fuel Flow Rate using three different Fuels37 Figure 15 Variation of TIT with Bypass Ratio at Constant Fuel Flow Rate using three different Fuels37 Figure 16 Variation of Exit Velocity Ratio with Byp ass Ratio at Constant Fuel Flow Rate using three different Fuels38 Figure 17 Variation of LPT Exit Pressure Ratio with Bypass Ratio at Constant Fuel Flow Rate using three different Fuels39 Figure 18 Variation of Net Thrust with Bypass Ratio at Constant Fuel Flow Rate using three different Fuels40 Figure 19 Variation of Specific Fuel Consumption with Bypass Ratio at Constant Fuel Flow Rate using three different Fuels41 Figure 20 Variation of Thermal Efficiency with Bypass Ratio at Constant Fuel Flow Rate using three different Fuels42 Figure 21 Variation of Propulsive Efficiency with Bypass Ratio at Constant Fuel Flow Rate using three different Fuels43 Figure 22 Variation of Fuel-Air-Ratio with Bypass Ratio at Constant TIT using the three Different Fuels44 Figure 23 Variation of Exit Velocity Ratio with Bypass Ratio at Constant TIT using the three Different Fuels44 Figure 24 Variation of LPT Exit Pressure Ratio with Bypass Ratio at Constant TIT using the three Different Fuels45 Figure 25 Variation of Net Thrust with Bypass Ratio at Constant TIT using the three Different Fuels46 Figure 26 Variation of Specific Fuel Consumption with Bypass Ratio at Constant TIT using the three Different Fuels46 Figure 27 Variation of Propulsive Efficiency with Bypass Ratio at Constant TIT using the three Different Fuels47 Figure 28 Variation of Thermal Efficiency with Bypass Ratio at Constant TIT using the three Different Fuels48 Figure 29 Variation of Exergy Destruction Rate Using the three Fuels for Analysis Case 262 Figure 30 Variation of Exergy Destruction Rate Using the three Fuels for Analysis Case 364 Figure 31 Variation of Exergetic Efficiencies Using the three Fuels for Analysis Case 266 Figure 32 Variation of Exergetic Efficiencies Using the three Fuels for Analysis Case 367 Figure 33 Distribution of Exergy Improvement potential Rate Using the three Fuels for Analysis Case 268 Figure 34 Distribution of Exergy Improvement potential Rate Using the three Fuels for Analysis Case 369 Figure 35 variation of Fuel Depletion ratio using the Three Fuels for Analysis Case 270 Figure 36 variation of Fuel Depletion ratio using the Three Fuels for Analysis Case 371 Figure 37 Grassmann Diagram for the Exergetic analysis of Case 2 using kerosene Fuel for the Turbofan engine. 72 Chapter 1 Introduction Jet engines are complex thermodynamic systems that use a series of non-linear equation to define their thermodynamic processes and they operate under the principle of Brayton cycle.Brayton cycle is a cycle that comprises of the compressor, combustor and turbine working as a unit. Additionally, the major parameters that dictate the operational conditions of the engine at any point during the process are the relative altitude and Mach number. Mach number is the ratio of the velocity of the jet engine to the speed of sound. Basically, the main purpose of this type of thermodynamic system in aerospace industry is to accelerate a jet of air and as a result, generate enough thrust needed for flight. In addition, the design of jet engines is dependent of what purpose it will be used for in order to derive its maximum performance.For instance, in military application, jet engines are required to generate maximum thrust in minimum response time which consumes a lot of fuel whereas commercial jet engines are required to less noise generative, less fuel consuming and at the same time have high overall efficiency (El-sayed, 2008). There are certain factors that jet engine manufacturers take into consideration when designing jet engines which are the operating cost, engine noise, environmental emissions, fuel burn and overall efficiency. Accordingly, this has caused a global market competition for engine manufacturers like Rolls Royce, Pratt and Whitney, General Electric and CFM on who can produce the most efficient jet engines.In fact, Pratt and Whitney Company is working on a geared turbofan jet engine that they believe will reduce fuel burn, produce lesse r noise and emit less toxics while General Electric is coming up with simpler â€Å"ecore† jet engines that will be more fuel efficient than the current jet engines with as much as almost two fifths of current jet engines (Cassidy, 2008). Taking all that has been said into consideration, it can easily be asserted that by reducing the fuel consumption of the jet engine, the total temperature at the turbine blades will reduce thereby increasing the operating life and overall efficiency of the engine. Also, the total cost of the engine can be cut down. Indeed, Dr Pallan cited in (Ward, 2007) stated that reducing the fuel consumption by as little as 1% is highly longed after by engine manufacturers and this can result in very significant increase in the overall performance.In a general point of view, it can be said that the maximum point of achievement for jet engine manufacturers would be to design an engine that consumes the minimum amount of work in the compressor unit while g enerating the maximum amount of work in the turbine unit at minimum fuel supply. The main purpose of this work is to analyse the thermodynamic processes and performance of a jet engine using a simulation tool, exergy and thermoeconomics concept. 1. 1. Aims and Objectives The main objective of this work is to carry out the thermodynamic analysis and show the performance characteristics of a turbofan jet engine. In this work, the vivid explanation of the thermodynamics processes and cycle of each component of the turbofan engine starting from the diffuser to the nozzle will be covered. Also, the first and second law of thermodynamics with other laws will be applied extensively throughout this work.However, in the aspect of performance characteristics of the turbofan engine, a generic simulation will be carried out on a twin spool mixed flow turbofan engine. To relate this work to real life application, a JT8D-15A turbofan engine manufactured by Pratt and Whitney Company will be used a s the twin spool mixed flow turbofan for the simulation using the original design data. Indeed, the simulation tool that will be used is GasTurb 11 which was designed by Joachim Kurke and for more details on how it works can be found in (Kurke, 2007). This work will use the reference design point of the twin spool mixed flow turbofan at sea level with maximum take-off thrust to obtain the operating point of 30,000ft at M0 0. using the off-design performance simulation which will serve as the operating design point for the analysis in this work since the engine will spend most of its time in the cruise phase between 30000ft to 38000ft. The purpose of carrying this generic simulation of the turbofan engine is to investigate the effects of varying bypass ratio and turbine inlet temperature (thermal limit parameter) on the performance characteristics of the turbofan engine. In other words, the parametric cycle studies of the turbofan engine. This investigation will be done for three dif ferent cases which case 1 will be studying the effects of varying bypass ratio and turbine inlet temperature on the performance characteristics of the turbofan engine when some of the design choices are kept constant.The second case of study will be the comparison of the performance characteristics of the turbofan engine when three different fuels (kerosene, natural gas and Hydrogen) are used at the same mass flow rate using the same design point in case 1. Finally, the third case of study will be the comparison of the performance characteristics of the turbofan engine when the three fuels are undergoing the same combustion process that is constant turbine inlet temperature for the design point in case 1. This aspect of this analysis is very important owing to the growing problem of greenhouse effect and depletion of energy resources. In fact, statistics by the intergovernmental panel shows that aerospace industry is amongst one of the fast growing sources of greenhouse effect and t hat the emission of carbon dioxide will increase to five times what it is presently which is 3% (Symonds, 2005).Based on this, using alternative fuels like hydrogen and natural gas can tend to reduce pollution and consumption of energy resources risk and this work aims to show how that can be achieved while the overall efficiency of the engine is still high. Another approach of analysis in this work will be the use of the second law of thermodynamics analysis also known as exergy and thermoeconomics. This aspect of analysis of the turbofan engine will be done for the parametric analysis of case 2 and case 3 in efforts to also compare the three fuels that are being considered and show which fuel will cause the turbofan engine components to be most inefficient or have the most irreversibility.This analysis will be done by calculating the exergy relationships such as exergy transfer rates, exergy destruction rates, exergetic efficiencies, exergy improvement potential rates, and fuel de pletion ratios. Furthermore, the exergy analysis will be represented in a Grassmann diagram for parametric analysis case 2 of study. However, as for the thermoeconomics analysis of the turbofan engine, only parametric analysis case 3 studies will be done for only kerosene fuel and this work will aim to show how to use concept of local and global evaluation of thermoeconomic cost. 1. 2. Computational Modelling It will be very expensive and time wasting to design and develop new aircraft engine whenever an optimization or analysis wants to be done.In fact, Caoa Y, Jin, Meng and Fletcher (2005) stated that new ways should be developed to reduce aircraft engine design, maintenance and manufacturing cost in order to have effective worldwide market competition. Surprisingly, computer modelling is one approach of reducing manufacturing cost and time wasting. Computational modelling can simply be defined as the use of computer codes to replicate a typical system using some of its original d ata in order to analyse the system at varying conditions. The other side of the medallion shows simulation. There are many types of simulation tools normally used in simulating gas turbines such as Matlab/simulink, Modelica, Gas Turb 11, NPSS and many more. However, the simulation tool that will be adopted for the purpose of this dissertation is Gas Turb 11 designed by Joachim Kurzke.Gas Turb 11 is a language oriented program with a command prompt that calculates the output data without using block diagrams or graphical interface. It is user friendly in a sense that it is easy to find the tools library and to substitute data in for simulation. The Gas Turb 11 is specifically designed for simulation of all kinds of gas turbines starting from power generators to jet engines. Gas Turb 11 usually carries out two types of analysis which are the on design cycle point simulation and off-design cycle point simulation. Engine design point cycle simulation involves the study of comparing gas turbines of different geometry. This cycle design point must be defined before any other simulation can be done.On the other hand, off-design performance cycle point simulation involves the study of the behaviour of a gas turbine with known geometry. This cycle outlines the performance characteristics of each component such as performance maps, Overall efficiency. The type of simulation that will be done in this dissertation will involve the off-design and design point cycle. Chapter 2 Jet Engines 2. 1. Performance Parameter of Jet Engines 2. 2. 1. Thrust Thrust is the way of quantifying the ability of a jet engine to effectively utilise the energy added to it in order to propel or push itself forward in the opposite direction of the exiting jet in the exhaust nozzle.In other words, it is the reactive force to the force imparted by the exiting jet in the nozzle in accordance to Isaac Newton’s third law of motion. It is the most important parameter that has to be obtained for any jet engine and it depends heavily on the ingested mass of air, exiting velocity and pressure, the area of the nozzle, the flight velocity and ambient conditions. In fact, the mathematical expression for thrust which incorporates these factors is shown below as. Thrust=meVe-m0V0+Pe-P0Ae Where, e=the exit conditions at the exhaust nozzle, 0=ambient conditions at the inlet me=m0+mfuel Momentum Thrust=meVe; This is the thrust obtained from the reaction of the hot exhaust gases high velocity.Momentum Drag= m0V0 ; This the friction or drag force caused by the high velocity ingestion of air mass at the inlet. Pressure Thrust=Pe-P0Ae; This force is generated as a result of the higher exit static pressure compared to the ambient pressure which pushes back at the engine. Gross Thrust=meVe+Pe-P0Ae; It is the maximum obtainable positive thrust a jet engine can have when the drag forces are ignored. Special Cases of Thrust Take-off Thrust It is the thrust a jet engine can generate with its o wn power at static or low power setting which means the momentum drag component of thrust is ignored and the power of the engine at this point is equivalent to zero.This can be used to explain why the thrust of an engine at take-off condition is usually higher than at cruise condition since there is no momentum drag and effects of varying ambient condition. This only applies to turbojet, turbofan, and turboprop jet engines but when it comes to ramjet and scramjet, the air flow has to be accelerated by a booster system before it can start producing a positive take-off thrust. Pressure Thrust Component This is the thrust generated as a result of the static pressures of the exiting jet and ambient environment. In ideal cases where the nozzle has perfectly expanded the jet exit pressure to that of the ambient condition, the pressure thrust component will disappear which this case is not possible in reality.However, if the nozzle is choked which indicates that the ambient pressure is low er than the exit pressure of the jet, the pressure thrust component will have a positive effect on the net thrust. Also, if the nozzle tends to over expand the jet because of low energy addition to the jet and the exit pressure is lower than the ambient pressure, the pressure thrust component will have a negative effect on net thrust. 2. 2. 2. Thermal efficiency It is simply the measure at which energy in the engine system is converted. In other words, it is the measure at which total energy supplied to the engine system as heat transfer is converted to kinetic energy.In another way, it can easily be said to be the ratio of the power generated in the engine airflow to the rate at which energy is supplied in the fuel. ?TH=Power Generated in the Engine AirflowRate of Energy Supplied in the Fuel =12? meVe2-12? m0V02mfuel? NCV 2. 2. 3. Propulsive efficiency It is a measure at which kinetic energy possessed by air as it passes through the engine is converted into power of the propulsion of the engine. In mathematical terms, it is simply known as the ratio of thrust power to the power generated in the engine airflow. ?p=Thrust PowerPower Generated in the Engine Airflow = T? V012? meVe2-12? m0V02 2. 2. 4. Overall EfficiencyAs the name overall depicts, it is the resultant efficiency of a jet engine can have which is simply the product of the thermal and propulsive efficiencies. In mathematical terms, it is represented as shown below. ?O=? TH p =12? meVe2-12? m0V02mfuel? NCV? T? V012? meVe2-12? m0V02 =T? V0mfuel? NCV 2. 2. 5. Specific Fuel Consumption Specific fuel consumption as any other performance characteristics is a ratio and surprisingly it has a major effect on the economics of the aircraft as it is used to determine the aircrafts flight ticket costs. Specific fuel consumption has different expressions depending on what type of jet engine it is. For instance, in ramjet, turbojet and turbofan jet engines, it is the measure of the fuel mass flow rate to the thrus t force generated.Also, it is sometimes called the thrust specific fuel consumption (TSFC). TSFC=mfT However, in turbopropeller jet engines, it is the ratio of the fuel mass flow rate to the power generated in the engine shaft by the turbomachinery. It is sometimes referred to as the brake-specific fuel consumption (BSFC). TFSC=mfSP 2. 2. Fuel and Propellants for Jet Engines Fuels can implicitly be defined as substances used to add heat energy to a system through combustion or other processes. Fuels are mostly hydrocarbons like kerosene, diesel, petrol, alcohol, paraffin and butane and can also be in the form of individually free reactive molecular substances like hydrogen or chemical composites like natural gas, coal, wood.The gaseous state substances used as fuels such as hydrogen, and natural gas (94% methane and 6% ethane) are usually made into a cryogenic state as in liquefied at very low temperature because of their low boiling point. It can easily be asserted by anyone that t he only purpose that fuels have in jet engines is to add energy but little do they know that the purposes grows as the speed of the aircraft increases. For instance, Kerrebrock (2002) stated that supersonic aircrafts which attains very high stagnation temperature that can create destabilization to the airframe structure, engine component and organic substances like lubricants, uses its fuel as a coolant to this parts or components.The energy added by the fuel burned per unit mass of air flow is called the heating value of the fuel and it is a very crucial parameter to be defined before any combustion process analysis is done on a jet engine since it shows how complete the combustion process is through efficiency. The heating value can either be said to be higher or lower depending on if the water product of combustion is a vapour or a liquid. Since the combustion process in jet engine produces vaporised water, the lower heating value of the fuel is used. The most frequently used fue ls for jet engines are kerosene jet A1, A2, JP10 and many more but diesel can also be used. The disadvantages of these fuels are their inevitable emission of toxic substances that contribute to greenhouse effect and their risk of depletion.Accordingly, this has been the driving force for the use of alternative fuels such as cryogenic hydrogen and natural gas which is believed will reduce toxic emissions. Besides, hydrogen is a carbon-free energy carrier and possesses almost no risk of toxic emission since most of its combustion product will be water Chiesa and Laozza (2005). Chapter 3 Turbofan Jet Engine 3. 1. Introduction Between 1936 and the next decade when turbofan engines were invented, people showed little or no interest in them as they described them to be a complicated version of a turbojet engine. However, in 1956, the benefits of turbofan engines started to be noticed as major companies like Rolls-Royce and General Electric began manufacturing them.Since then, it is been o ne of the most used jet engine for commercial purposes because of its low fuel consumption and less noise production. In fact, it has been concluded to be the most reliable jet engine ever manufactured El –Sayed (2008). The turbofan jet engine gas generator unit comprises of a fan unit, compressor section, combustion chamber and turbine unit. Fundamentally, a turbofan jet engine operates as a result of the compressors pressuring air and supplying it afterwards for further processing. The majority of the pressurised air is bypassed around the core of the engine through a duct to be mixed or exhausted whereas the rest of it flows into the main engine core where it combusts with the fuel in the combustion chamber.The hot expanded gas products from the combustion process passes through the turbine thereby rotating the turbine as it leaves the engine. Consequently, the rotating turbine spins the engine spool which in turn rotates the other turbo machinery in the engine. This cause s the front fan to pressurise more and more air into the engine for the process to start all over again in continuous state. The turbofan engine is believed to be the perfect combination of the turboprop and turbojet engine and as a result, its advantages are usually compared to that of the turboprop and turbojet. In fact, Kerrebrock (1992) said that turbofan engine provides a better way of improving the propulsive efficiency of a basic turbojet.It is asserted that at low power setting, low altitude condition and low speed, the turbofan engine is more fuel efficient and has better performance than a turbojet engine. Unlike turboprop engine where vibration occurs in the propeller blades at relative low velocities, the fan in the turbofan engine can attain high relative velocities of Mach 0. 9 before vibration occurs. Also, since the fan in turbofan engines has many blades, it is more stable than the single propeller so even if the vibration velocity is reached, the vibration will not destabilize the airflow because the vibrations are almost negligible. Since the flow into the diffuser of the turbofan is usually subsonic, there very slim chances of shock waves being developed at the entrance. 3. 2. Classification of Turbofan EnginesThere are various types of turbofan engine ranging from high and low bypass ratio, afterburning and non-afterburning, mixed and unmixed flow with multi-spool, after fan and geared or ungeared. The classification of the various types of turbofan engines is shown below in figure 1. Nonetheless, the type of turbofan engine that would be used for the purpose of this dissertation is a forward fan two spool mixed flow turbofan engine. This type of turbofan engine was chosen because it is the compromise of a simple and complex turbofan engine. This is said because it comprises of almost all the classes of a turbofan which are low bypass ratio, forward fan with mixed flow, twin spool with ungeared fan.Moreover, because of the mixed flow intro duced, it produces additional thrust in the hot nozzle compared to the high bypass and it can also permit the addition of afterburner which produces a lot of thrust while consuming a lot of fuel which makes it suitable for military application which shows little worry on fuel consumption. In essence, carrying out a study on this type of turbofan engine will be of great relevance to the military air force sector especially if new research is discovered. TURBOFAN ENGINES Low Bypass Ratio Aft Fan Forward Fan Nonafterburning Afterburning High Bypass Ratio Geared Fan Single Spool Short Duct Ungeared Fan Two Spool Mixed Fan and Core Flow Unmixed Flow Long Duct Three SpoolFigure 1 Classification of Turbofan Jet Engines (El-sayed, 2008) 3. 3. Major Components of Turbofan Engine 3. 4. 1. Diffuser or Inlet Diffuser is the first component that air encounters as it flows into the engine. Basically, the purpose of a diffuser is to suck in air smoothly into the engine, reduce the velocity of the air, increase the static pressure of the air and finally, supply the air in a uniform flow to the compressor. Given the fact that overall performance of an engine is highly dependent on the pressure supplied to the burner, it is necessary to design a diffuser that incurs the minimum amount of pressure loss.To demonstrate this, Flack (2005) stated that if the diffuser incurs a large total pressure loss, the total pressure in the burner will be reduced by the compressor total pressure ratio time this loss. In other words, a small pressure drop in the diffuser can translate into a significant drop in the total pressure supplied to the burner. Another point taken into consideration when designing a diffuser is the angle because if the angle is too big, there will be tendency of eddy flow generation due to early separation. The major causes of pressure losses in the diffuser are as follows. First, losses due to generation of shock waves outside the diffuser and it majorly occur in super sonic diffusers.Secondly, the loss due to the unfavourable or adverse pressure gradient of the diffuser geometry which makes the flow separate a lot earlier and generates eddies. This separation causes a convergent area which makes the velocity not to be reduced by much. Due to the separation, the wall shear deteriorates the static pressure even further. Further analysis done by El-Sayed (2008), describes ways of accounting for this losses like using Fanno line flow and combined area and friction. Thermodynamic Process Equation In this analysis, the loss due to heat transfer is negligible so the process can be adiabatic. The initial kinetic energy is used to raise the static pressure p0 to the total pressure ? =pt2pt0 (inlet pressure recovery) efficiency ? d=IdealReal=ht2s-h0ht2-h0 assuming the gas is ideal and the specific heat at constant pressure is constant efficiency ? d=Tt2s-T0Tt2-T0 simplifying the equation given that ht0=ht2=ht2s and Tt2=Tt0and pt2s=pt2 TtT0=1+? -12M02 and T tT0=ptp0? -1? pt2p0=1+ ? d? -12M02 -1 3. 4. 2. Fan And Compressors Compressor is a very crucial component for the operation of an engine in the sense that it prepares the air for the combustion process in the burner. The main purpose of a compressor as the first rotating component is to use its rotating blades to add kinetic energy to the air and later translate it into total pressure increase.There are basically two types of compressors which are the centrifugal and the axial compressor. Firstly, centrifugal compressor as the name implies changes the direction of an axial airflow to a radial outflow of the air. It was the early compressors adapted in jet engines. It comprises of three main parts which are the impellers, the diffusers and the compressor manifold. The purpose of the impeller is to change the direction of the flow from axial to radial and at the same time increases its static pressure. The diffuser slows down the airflow and further increase the static pressure as it is supplied axially by the compressor manifold to the combustion chamber.The centrifugal compressor is advantageous because the cost of manufacturing it is low compared to axial compressor and as a result is suitable for small engines like turboshafts and turboprops. It is also advantageous because the pressure ratios at single stage are higher than that of the axial compressor. The centrifugal compressor has the tendency of attaining low flow rates and as a result is ideally suitable for helicopters and small aircrafts which require low flow rates. On the other hand, the centrifugal compressor cannot attain high pressure ratio and so it is not suitable when high peak efficiency is required. It incurs a lot of losses due to the change in direction. Secondly, an axial compressor is the most reliable type of compressor and is usually applied when higher pressure ratios of up to 40:1 are required.An axial compressor does not change the axial flow direction of the air but increases the total pressure. Indeed, an axial compressor comprises of three major components which are the rotor with blades, stator can and the inlet guide vane. A stage is a combination of a stator and a rotor. The assembly of the full rotor blade and stator can form the number of stages in a compressor and the greater the number of stages, the higher the total pressure ratio. In this arrangement, the air flows into the inlet guide vane and then into the rotor and stator assembly where compression starts. Also, the length of the rotor and stator reduces along the whole unit which signifies a reduction in volume which induces the increase in pressure.A fan or low pressure compressor is a type of axial compressor but the only differences are that the blades are longer, the total pressure ratio is lower than the typical compressor and the number of stages is usually 1 or 2. The main purpose of creating a fan is to compress more air and to create a bypass air which can be used to generate addition thrust or used for mixing process. Fan Equation Process Given that, isentropic efficiency ? fan= Ideal CycleActual cycle=ht3s-ht2ht3-ht2 Since the specific heat is constant, the equation deduces to ? fan=Tt3s-Tt2Tt3-Tt2 Simplifying the equation whenpt3s=pt3, Tt3sTt2=pt3pt2? -1? , ? fan=pt3pt2 and ? fan=Tt3Tt2 ? fan=? fan? -1? -1? fan-1 Bypass Ratio=msma where ms is the bypass flow rate and ma is the engine core flow rate.For the high pressure compressor, the equations remain the same as that of the fan except the changes in station numbering and the bypass ratio. 3. 4. 3. Combustion Chamber/ Burner The combustion chamber as the Brayton cycle implies is the only source of heat energy addition to the system. Accordingly, the combustion chamber causes very significant increase in the temperature of the air which results in the air gaining enormous internal energy. This energy gained is extracted to be used to power the turbine while the rest is used to create highly accelerated gases from the nozzle. There are three types of combustor namely; the can combustor, the annular combustor and the cannular combustor.The main considerations when designing a combustion chamber is to ensure that the combustion process is complete with no fuel waste, the combustor should have long life materials because any failure can lead to engine explosion. The other consideration is that the air must be heated enough above the ignition fuel temperature in order to ensure stoichiometric combustion. Equations of the Combustion Chamber In the real process of the combustor, total and static pressure drops and the temperature also drop. The major causes of pressure losses are the high level of irreversibility or non-isentropic process and viscous effects in the burner. The burner pressure ratio ? =pt5pt4Burner temperature ratio ? b=Tt5Tt4 Since no work is done only heat transfer, the efficiency of the burner is analysed using the heating value NCV of the fuel used. Thus, efficiency ? b=hea t addedHeating value of fuel=ma+mfht5-maht4NCVmf Given that f=mfma, ? b= 1+fht5- ht4NCVf Equivalence Ratio of combustion It is the ratio of the actual fuel to air ratio of the combustion process to the stoichiometric fuel to air ratio. This ratio produces a means of classifying the combustion process to show whether it is a lean, rich or stoichiometric combustion. The mathematical expression for this is as shown below ? =Actual FARStiochiometric FAR 1 Rich combustion process 3. 4. 4. Turbine Turbine can simply be said to be the antonym of a compressor. In response, a turbine extracts molecular kinetic energy from the air and uses it to drive the turbo machineries which results in the pressure and temperature of the air to drop. If truth be told, Flack (2005) asserted that the turbine uses 70% to 80% of the total energy gained by the air in the combustion chamber to drive the turbo machineries while the remaining 20% to 30% is used to generate thrust in the nozzle.Since the geometry of a turbine have favourable pressure gradient unlike the compressor which is adverse, the efficiency of the turbine is usually very high. Since the turbine is the opposite of the compressor, it has exactly the same configuration of rotor and stator but the volume increase across it which induces the pressure drop. One major problem faced when design a turbine is the deterioration of the blades due to high inlet temperature from the combustion chamber. Based on this, (Song et al. 2002) demonstrated that General Electric uses about 16. 8% of the compressor air to cool the turbine blades of GE 7f engine. Turbine Equation Analysis Given that, Turbine efficiency ? T=ActualIdeal=ht6-ht5ht6s-ht5 T=Tt6-Tt5Tt6s-Tt5 Simplifying the equation given that pt6s=pt6 Tt6sTt5=pt6pt5? -1? ?T=pt6pt5 ? T=Tt6Tt5 ?T=? T-1? T? -1? -1 3. 4. 5. Exhaust Nozzle The nozzle is the final component of the jet engine that the air passes through. The main purposes of the nozzle is to add extra acceleration to the h igh velocity exiting air, reduces its total pressure to that of ambient condition and finally generate sufficient thrust. There are two conditions that occur in the exit of the nozzle depending on the ambient pressure. The first condition is termed under-expansion which occurs when the ambient pressure is less than the exit pressure of the gases.The result of this is that the exit velocity will be lower than it normally is and this makes the momentum component of thrust to be lower than ideal. On the other hand, it will create a positive thrust component for the pressure terms. The second case termed as overexpansion which occurs when the ambient pressure is greater than the exit pressure of the gases. Consequentially, the opposite of what happens in the under-expansion condition occurs where the pressure term is lower and the momentum is higher. Nozzle efficiency ? n=ActualIdeal=ht8-h9ht8-h9s=Tt8-T9Tt8-T9s for constant specific heat Using the steady state energy equation and balanc ing it out, U9=2ht8-h9 . When specific heat is constant U9=2cpTt8-T9 p9pt8=T9sTt8? -1? T9Tt8=11+? -12M92 p9pt8=11+? -12M92-1+ ? n ? n 3. 4.Thermodynamic Process and Cycle of Twin Spool Mixed Flow Turbofan Engine Before any explanation is done from Figure 2, the blue arrows represent the incoming air into the diffuser and the red represent the air flow into the core of the engine while the black arrow represent the bypass air flow through the fan. Finally, the brown arrow represents the air flow after the bypass air and the core air flow have mixed. Based on the arrangement of the turbofan engine in figure 2, it can be seen that air at ambient condition is sucked into the diffuser where the air velocity is reduced and some of its kinetic energy is used to increase the static pressure to the total pressure. The air exiting the diffuser enters the fan or low pressure compressor where it is compressed. Indeed, the molecules of the air gains kinetic and internal energy by colliding rapid ly with one another and as a result increase the enthalpy and static pressure.Also, in the fan, some of the compressed air is bypassed through a duct to be used for the mixing process later while the rest of the air enters into the high pressure compressor of the engine core. In the high pressure compressor, the air is further compressed where the enthalpy and pressure increases as it is released into the combustion chamber. Also, in the high pressure compressor, some of the air mass flow rate is bled out to be used to cool the turbine blades and for air conditioning in the aircraft. In the combustion chamber, the incoming fuel reacts with the air in an oxidation process at constant pressure where the by-product gases gain molecular kinetic energy thereby increasing the enthalpy.This high temperature gases escapes into the high pressure turbine where it is expanded and the gases lose some of their kinetic molecular energy as it enthalpy and static pressure reduces. In other words, i t can be said that the molecular kinetic energy of the gases is being converted to mechanical work which is used to power the high pressure spool. Consequently, the gases enters into the low pressure turbine where it is further expanded to a lower pressure and enthalpy as their molecular kinetic energy is converted to mechanical work to power the low pressure spool. These gases escaping from the low pressure turbine enters the mixing zone or mixer after it has lost most of its total enthalpy and mixes with the bypassed cold air from the duct to further reduce its enthalpy as that of the cold air increases.In other words, the cold air absorbs some of the heat energy from the hot gases until they both attain equilibrium enthalpy. The mixture of the cold air and hot gases both escape at the same equilibrium enthalpy and pressure through the nozzle where their velocity is increased and the pressure is reduced considerably to that of the ambient condition. Furthermore, the exhausted high velocity gases is used to produced thrust for propulsion according to Newton’s third law of motion (In every action, there is equal and opposite reaction). 2 4. 5 6 4 13 0 HPC DIFFUSER FAN/LPC HPT LPT NOZZLE COMBUSTION CHAMBER 2. 5 3 5 8 16 BYPASS DUCT HP Spool LP Spool MIXING ZONEFigure 2 Layout of a Forward Fan Twin Spool Mixed Flow Turbofan Engine P0 P3 P4. 5 P5 P8 P6 P2. 5 P2 P13 P4 ENTROPY (S)(kJ/kg) TEMPERATURE (K) Figure 3 T-S Diagrams for the Forward Fan Twin Spool Mixed Flow Turbofan Engine Chapter 4 Mathematical and Gas Turb 11 Modelling of the Engine 4. 1. Station Numbering and Assumptions Station numbering is a very crucial step that has to be taken when analysis of any thermodynamic system involving many processes is to be done. Moreover, station numbering contributes immensely to showing how the properties of one process relate to another and how the interaction between these processes derives the functional relationship of the thermodynamic system.Returning to the work in hand, the station numbering system that has been adopted for this work on a JT8D-15A turbofan engine is in accordance with the Aerospace Recommended Practice (ARP) and it is shown in figure 2. Assumptions The following assumption were made based on Mattingly (2002) and Kurzke (2007) in order to perform the modelling as listed below * The air flow through the engine is assumed to be steady and one dimensional * The fan and the low pressure Compressor are driven by the low pressure turbine * The overall engine is assumed to have no bleeds in mass flow or power off-take in turbine. * The nozzle of the engine is choked which means the exit pressure will be greater than the ambient pressure. The air is assumed to act as a half ideal gas where the specific heat and ratio is dependent on temperature only. * The areas of each station of the engine is assumed to be constant 4. 2. Design Point Cycle Analysis of the Turbofan Engine The off-design or performance cycle analysis cann ot be done without the design point cycle being defined. The design point cycle in this analysis is obtained using exactly the same data used in the actual test analysis for a JT8D-15A turbofan engine operating at sea level with maximum take-off thrust as shown in (â€Å"JT8D Typical Temperature and Pressure†) and (â€Å"ICAO†). Some of the input parameters such as the isentropic efficiencies and pressure ratios from the actual test data had to be calculated.Since not all the input parameters were given from the actual test data, some of the parameters like inlet corrected mass flow rate, diffuser pressure ratio and efficiency; mechanical spool efficiency had to be guessed in order to complete the analysis and the data are represented below in Table 1. With all the Input Parameter being specified as shown in table 1, the design point cycle simulation of the JT8D-15A turbofan Engine using the Gas Turb 11 software can then be performed. All the steps taken to model the m ixed flow turbofan engine on Gas Turb 11 is clearly represented in the algorithm shown in figure 3 below. COMPONENT| INPUT PARAMETER| | DIFFUSER| Pressure Ratio (? d)| 1| | Inlet Corrected Mass Flow Rate (mc2)| 138. 618 kg/s| FAN| Pressure Ratio (? fan)| 2. 054| | Isentropic Efficiency (? fan)| 0. 78| | Bypass Ratio (? )| 1. 08| Low Pressure Compressor (LPC)| Pressure Ratio (? LPC)| 4. 7| | Isentropic Efficiency (? LPC)| 0. 88| | Nominal Low Pressure Shaft Speed (NLP)| 8160RPM| High Pressure Compressor (HPC)| Pressure Ratio (? HPC)| 3. 77| | Isentropic Efficiency (? HPC)| 0. 864| | Nominal Low Pressure Shaft Speed (NHP)| 11420RPM| Combustion Chamber (cc)| Pressure Ratio (? CC)| 0. 934| | Isentropic Efficiency (? CC)| 0. 99| | Burner Exit Temperature (TIT)| 1277. 15K| High Pressure Turbine (HPT)| Isentropic Efficiency (? HPT)| 0. 9| | HP Spool Mechanical efficiency (? m)| 1| Low Pressure Turbine (LPT)| Isentropic Efficiency (? LPT)| 0. 91| | LP Spool Mechanical efficiency (? m)| 1| T able 1 Input Parameters for the Design Point Cycle Simulation STARTSpecify all the input data gotten from the actual test data as shown in Table 1 Run the Gasturb 11 software and select mixed flow turbofan from the drag down Tab list. Set the scope to ‘More’, set the Calculation Mode as Design and click ‘Run’ Choose the Units to either Imperial or SI and Select the type of fuel from to drop down list to Kerosene, Natural Gas or Hydrogen Estimate the inlet Corrected mc2 Mass Flow rate to the FAN/LPC Choose ‘Single Cycle’ for ‘Select a Task ‘Option and click ‘Run’ Check if the Thrust, SFC, ? HPT, ? LPT and EPR are within (0-10) % of the actual test Experiment END YES NO Figure 4 Design Point Cycle Simulation Algorithm Using Gas Turb 11 Verification of the Design Point simulation ResultsSince not all the input parameters were specified in the actual test data and some of them had to be guessed, it is without any doubt that errors are bound to generate in the simulation results using the Gas Turb 11 software. In order to ensure that the errors accumulated in the simulation were within range, the major output parameters obtained such as net thrust, fuel flow rate, Engine exit pressure ratio, etc were compared to the actual test data as shown in Table 2 and the error range was calculated to be between 0. 25% to 8. 5% which is within an acceptable range. PARAMETERS| ACTUAL TEST DATA| SIMULATED DATA USING GASTURB 11| Net Thrust| 69307. 74| 69320| Engine Exit Pressure Ratio P8P0| 2. 09| 2. 167|Burner Fuel Flow| 1. 100843| 1. 09781| HPT pressure Ratio (? HPT)| 0. 415| 0. 449| LPT Pressure Ratio (? LPT)| 0. 3294| 0. 3514| HPT temperature Ratio (? HPT)| 0. 8097| 0. 8435| LPT temperature Ratio (? LPT)| 0. 7718| 0. 793| Table 2 Comparison Table for the Actual Test Data and Simulated Data Using GasTurb 11 4. 3. Off-Design Point Cycle Simulation of the Turbofan Engine The off-design or performance cycle simulatio n takes into account the concept of module matching of each component through performance maps. This cycle analysis enables the determination of different operating point of the engine at a given design point of the engine.Considering the work in hand, the design point have been defined and verified for the JT8D-15A turbofan engine operating at sea level with maximum take-off thrust which means that different operating points of the engine can be defined with the concept of off-design module matching of the engine. Indeed, the off-design operating point that was considered for the parametric analysis in this work was 30,000ft at M0 0. 8 for the turbofan engine. The off-design modelling of the JT8D-15A engine for the operating point of 30,000ft at M0 0. 8 based on the reference design point defined earlier is clearly demonstrated as follows. The off-design performance cycle simulation may contain some errors because of the component performance maps that were used for the simulation. 4. 3. 1. Module/Component Matching This process only applies to the off-design performance cycle point of the engine.It can simply be defined as the act of synchronising each component of a jet engine to coexist as a unit in order to derive the overall performance characteristics of the jet engine. Component matching involves the process closely studying the ramifications of the actual jet engine overall performance behaviour on the components major characteristics such as pressure ratio, temperature ratio, efficiency and spool speed. This process introduces the concept of empirically determined component performance maps that establishes the relationship between the thermodynamic properties and the geometry of the jet engine itself. 4. 3. 2. Off-Design Component Modelling Diffuser The diffuser was assumed to be adiabatic and the pressure ratio ? d=1 The Isentropic Efficiency was assumed to be 1 For Sea Level,Pamb=101325pa , Tamb=288. 15K For 30,000ft and M0 0. 8, Tamb=288. 15-0. 0 065? 9144 =288. 15-59. 436 =228. 71K Pamb=101325? Tamb288. 155. 2561 =30. 09kpa Tt1=228. 71? 1+? -12M02 =228. 71? 1+1. 4-12? 0. 82 =258K pt1p0=1+ ? d? -12M02 -1 pt1=30. 09? 1+ 1? 1. 4-120. 821. 41. 4-1 pt1=45. 8674kPa pt1=pt2 Tt1=Tt2 Fan and Low Pressure Compressor The inlet corrected mass flow rate is estimated as 138. 618kg/s , As for the off design simulation using the component performance maps for the altitude of 30000ft and Mach no. 0. 8, the actual spool speeds and inlet mass flow rate are calculated based on the estimated inlet corrected mass flow rate as shown below.Low and High pressure spool mechanical efficiency is assumed to be=1 HP spool Speed=11420RPM, LP spool Speed=8160RPM m2=Pt2PSTD? mc2Tt2TSTD =45. 878101. 325? 138. 618258288. 15 Actual Mass flow rate m2=66. 3323kg/s N=Tt2TSTD? NcLP=228. 71288. 15? 8160=7722 RPM The calculated actual mass flow rate and spool speed were used to evaluation the isentropic efficiency and the pressure ratio of the LPC for that operatin g condition from the compressor performance map. Figure 5 Example of a Compressor Performance Map/Curve The diagram above in figure 4 depicts a typical compressor performance map that was used for the off-design point analysis in this work.It can be seen that the x-axis represents the inlet corrected mass flow rate mc2 into the compressor, the y-axis represents the compressor pressure, the red contour lines represents the isentropic efficiencies and the black curved lines represent the relative corrected spool speed. To add to that, the red dash line that ends the speed lines and efficiency lines represent the surge margin which is also known as the stall line that must be avoided since the flow will become unstable in that region. In this work, the inlet corrected mass flow rate and spool speed were calculated which were interpolated on the performance map to obtain the pressure ratio and the isentropic efficiency.For instance, the yellow dot on the map represents a design point tr aced for a given pressure ratio, High Pressure Compressor The inlet corrected mass flow rate into the HPC mc2. 5=mc21+? mc2. 5=138. 6182. 08=66. 64kgs m2. 5=Pt2. 5PSTD? mc2. 5Tt2. 5TSTD N=Tt2. 5TSTD? NcHP The same equation used for the LPC is used to calculate the actual mass flow rate and spool speed which is used to evaluate the isentropic efficiency and pressure ratio when it is operating at an altitude of 30000ft at M0 =0. 8. Verification of the off-design modelling for 30000ft at Mo 0. 8 In order to verify the simulation result gotten for the operational design point of 30000ft at M0 0. , the actual test data results gotten from Mattingly, Heiser and Pratt (2002) for the same operating condition was compared. Due to the difficulties in obtaining a lot of output parameters for this operating point, the result will be verified with only the net thrust generated and the specific fuel consumption. Indeed, the error accumulated was 1. 71% for the net thrust and 0. 83% for the specif ic fuel consumption. PARAMETERS| ACTUAL TEST DATA| SIMULATED DATA USING GASTURB 11| Net Thrust (lb)| 4920| 4836| Specific Fuel Consumption(lb/lbh)| 0. 779| 0. 7855| Table 3 Comparison Table for the Actual Test Data and Simulated Off-design Data Using GasTurb 11 Chapter 5Methodology, Results and Discussions Given that the design point of the JT8D-15A turbofan engine at sea level has been obtained and verified with the actual test data, the operating point of 30000ft at M0 0. 8 was simulated and obtained which now served as the design point for the analysis in this work. Moreover, the procedure taken to define this design point of 30000ft at M0 0. 8 of the JT8D-15A turbofan engine has been clearly stated earlier which gives the permission to conduct the parametric cycle study of the turbofan engine. The parametric cycle studies were done for three different cases for the operational design point of 30000ft at M0 0. of the JT8D-15A turbofan engine as explained as follows. 1. The first parametric analysis case 1 aim to create an understanding of the effects of varying major design parameters on the performance parameters of the turbofan engine when some of the design choices are kept constant. In other words, the bypass ratio and thermal limit parameter (turbine inlet temperature) were varied when the design choices such as the compressor pressure ratio, fan pressure ratio and isentropic efficiencies were kept constant in order to investigate their effects on the performance parameters such as the net thrust, specific fuel consumption, propulsive efficiency, thermal efficiency, and fuel-air-ratio.Much interest is shown nowadays in using alternative fuels like hydrogen and Natural gas in efforts to reduce the cancer known as pollution and the risk of depletion of energy resources. Based on this, conducting a research that focuses of comparing different fuels consumption rate, their risk of pollution and their contribution to the performance of the engine will be re ally valuable. Based on this, a parametric analysis had to be done on the JT8D-15A turbofan engine using three different fuels which are the design point fuel kerosene, hydrogen and natural gas. Since the original design point of the JT8D-15A turbofan was obtained using kerosene fuel, the design points of using hydrogen and natural gas was obtained using the same design choices as that of kerosene.Now that the design points of the JT8D-15A turbofan engine had been defined when using the three different fuels, it had given a go ahead to perform whatever parametric cycle studies of the turbofan engine using the three fuels. In order to compare the performance characteristics of the turbofan engine when it is using the three different fuels, different approaches had to be devised to compare them effectively on a rational basis which defines the last two parametric analysis cases as follows. 2. The second case of parametric analysis was that the fuel flow rate would be kept constant for the three fuels that would be used as the bypass ratio is varied with design choices remaining the same. 3.The third case of study was to make the energy supply into the combustion chamber of the turbofan engine the sa